About: BRCA mutation   Goto Sponge  NotDistinct  Permalink

An Entity of Type : yago:PhysicalCondition114034177, within Data Space : wasabi.inria.fr associated with source document(s)

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. T

AttributesValues
type
label
  • BRCA mutation
  • Mutação BRCA
  • Μετάλλαξη BRCA
  • طفرة BRCA
comment
  • A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. T
  • Uma mutação BRCA é qualquer mutação genética que ocorra nos genes supressores de tumores BRCA1 ou BRCA2. Estão identificados centenas de diferentes tipos de mutações, sendo muitas inofensivas enquanto outras são nocivas. As mutações nocivas nestes genes podem aumentar o risco de desenvolver vários tipos de cancro, sobretudo cancro da mama e cancro do ovário.
  • Ως μετάλλαξη BRCA ορίζεται η μετάλλαξη που προκαλείται σε κάποιο από τα γονίδια BRCA1 και BRCA2. Οι παθολογικές μεταλλάξεις σε αυτά τα γονίδια προκαλούν το σύνδρομο του κληρονομικού καρκίνου του μαστού και των ωοθηκών. Αν και ο καρκίνος του μαστού είναι σχετικά κοινός, οι μεταλλάξεις στα BRCA1 και BRCA2 είναι σπάνιες, επομένως οι μεταλλάξεις αυτές είναι υπεύθυνες για το μόλις 5 έως 10% των περιπτώσεων καρκίνου του μαστού στις γυναίκες.
  • طفرة BRCA هي طفرة في أيا من جينات و BRCA2، وهي جينات قامعة للورم. تم تحديد مئات الأنواع المختلفة من الطفرات في هذه الجينات، البعض منها قد ثبت أنه ضار، في حين أن البعض الآخر ليس له تأثير مثبت. قد تحدث طفرات ضارة في هذه الجينات متلازمة سرطان الثدي المبيض الوراثي في الأشخاص المتضررين. تُعزى فقط 5-10٪ من حالات سرطان الثدي لدى النساء إلى طفرات BRCA1 و BRCA2 (مع ان طفرات BRCA1 أكثر شيوعًا بشكل طفيف من طفرات BRCA2) ، ولكن التأثير على
sameAs
name
  • BRCA mutation
name
  • BRCA mutation
topic
Faceted Search & Find service v1.13.91 as of Mar 24 2020


Alternative Linked Data Documents: Sponger | ODE     Content Formats:       RDF       ODATA       Microdata      About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software