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In enzymology, the committed step (also known as the first committed step) is an effectively irreversible enzymatic reaction that occurs at a branch point during the biosynthesis of some molecules.As the name implies, after this step, the molecules are "committed" to the pathway and will ultimately end up in the pathway's final product. The first committed step should not be confused with the rate-determining step, which is the slowest step in a reaction or pathway. However, it is sometimes the case that the first committed step is in fact the rate-determining step as well.

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  • Committed step
  • 關鍵步驟
  • 개입단계
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  • 酵素學中，關鍵步驟(Committed step；也被稱為第一關鍵步驟，first committed step)，發生於某些分子的生化合成反應之分歧點上，且可有效使需酶促反應之逆向進行。 如同其名稱所示，經過此步驟後，分子被”指定”(committed)到特定的代謝路徑中，最後仍會出現於此途徑的最終產物中。第一關鍵步驟不應該與速率決定步驟混淆，速率決定步驟為反應或代謝路徑中反應最慢的步驟。然而，在某些例子中，反應的第一關鍵步驟等同為速率決定步驟。
  • In enzymology, the committed step (also known as the first committed step) is an effectively irreversible enzymatic reaction that occurs at a branch point during the biosynthesis of some molecules.As the name implies, after this step, the molecules are "committed" to the pathway and will ultimately end up in the pathway's final product. The first committed step should not be confused with the rate-determining step, which is the slowest step in a reaction or pathway. However, it is sometimes the case that the first committed step is in fact the rate-determining step as well.
  • 개입단계(介入段階, 영어: committed step)는 효소학에서 커밋된 단계 또는 조절의 핵심 즉, 일부 분자의 생합성 동안 분지점에서 발생하는 효과적으로는 돌이킬 수 없는 효소 반응이다. 이름에서 알 수 있듯이 이 단계가 끝나면 분자가 경로에 "커밋"되고 결국에는 경로의 개시적인 생산물이 된다. 첫 번째 커밋된 단계는 반응 또는 경로에서 가장 느린 단계인 속도 결정 단계와 혼동해서는 안된다. 그러나 때로는 첫 번째 커밋된 단계가 실제로 속도 결정 단계인 경우일 수도 있다.
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