In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability.
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| - Iron Response Element
- Iron response element
- Élément de réponse au fer
- IRE (биология)
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| - Das Iron Response Element (IRE, engl. etwa auf Eisen reagierendes Element) ist eine Struktur in einer mRNA, die eine Regulation der von dieser RNA ausgehenden Proteinsynthese (Translation) in Abhängigkeit von der Verfügbarkeit von Eisen in der Zelle erlaubt. IREs spielen dadurch eine zentrale Rolle bei der Kontrolle der Genexpression des Eisen-Stoffwechsels in Tieren. Sie finden sich dagegen nicht in Pflanzen oder Pilzen.
- Железозави́симый элеме́нт (англ. Iron response element, IRE) — особый регуляторный элемент, содержащийся в 5′-нетранслируемой области мРНК белков, как правило, участвующих в метаболизме железа. Наиболее известным белком, мРНК которого содержит IRE, является ферритин, связывающий Fe3+. Регуляция, осуществляемая IRE, зависит от концентрации железа в клетке. IRE встречаются у самых разнообразных эукариот, но мало представлены среди растений.
- L'élément de réponse au fer ou IRE (iron-response élément) est un segment d'ARN, capable d'adopter une structure en tige-boucle spécifique. On trouve un ou plusieurs IRE sur les ARNm codant des protéines impliquées dans la régulation de la concentration intracellulaire de fer chez de nombreux eucaryotes : la ferritine, le récepteur de la transferrine TfR1, l'enzyme ALAS2, l'aconitase ACO2, l'enzyme (en), la ferroportine ou encore le transporteur (en).
- In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability.
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| - Iron response element
- Iron response element - Model I
- Iron response element - Model II
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| - Das Iron Response Element (IRE, engl. etwa auf Eisen reagierendes Element) ist eine Struktur in einer mRNA, die eine Regulation der von dieser RNA ausgehenden Proteinsynthese (Translation) in Abhängigkeit von der Verfügbarkeit von Eisen in der Zelle erlaubt. IREs spielen dadurch eine zentrale Rolle bei der Kontrolle der Genexpression des Eisen-Stoffwechsels in Tieren. Sie finden sich dagegen nicht in Pflanzen oder Pilzen.
- Железозави́симый элеме́нт (англ. Iron response element, IRE) — особый регуляторный элемент, содержащийся в 5′-нетранслируемой области мРНК белков, как правило, участвующих в метаболизме железа. Наиболее известным белком, мРНК которого содержит IRE, является ферритин, связывающий Fe3+. Регуляция, осуществляемая IRE, зависит от концентрации железа в клетке. IRE встречаются у самых разнообразных эукариот, но мало представлены среди растений.
- L'élément de réponse au fer ou IRE (iron-response élément) est un segment d'ARN, capable d'adopter une structure en tige-boucle spécifique. On trouve un ou plusieurs IRE sur les ARNm codant des protéines impliquées dans la régulation de la concentration intracellulaire de fer chez de nombreux eucaryotes : la ferritine, le récepteur de la transferrine TfR1, l'enzyme ALAS2, l'aconitase ACO2, l'enzyme (en), la ferroportine ou encore le transporteur (en).
- In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability.
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| - Predicted secondary structure and sequence conservation of IRE
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