About: Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

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About: Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy
Creator	Baldanti, Fausto Piralla, Antonio Bianchini, Sonia Caimmi, Silvia Esposito, Susanna Girello, Alessia Lunghi, Giovanna Principi, Nicola Ruggiero, Luca Giardina, Federica De Sando, Elisabetta Marseglia, Gian
topic	covid:0079559ab8717d83bc3df6be8533ff9672bb4367#this
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: In recent years, several outbreaks due to Enterovirus D-68 (EV-D68) have been reported, and it was confirmed that the virus can cause upper and lower respiratory tract diseases and be associated with the development of neurological problems. OBJECTIVES: The main aim of this research was to study the genetic characteristics of EV-D68 strains that were circulating in Italy identified during an outbreak of an EV-D68 infection that occurred in Italy during the period March-October 2016. STUDY DESIGN: A retrospective study of the circulation of different types and subtypes of EV-D68 was performed. Nasopharyngeal swabs were collected from March 2016 through October 2016 in children admitted to the Emergency Room with respiratory diseases. RESULTS: Among 390 children, 22 (59.1% males; mean age 47 months) were found to be infected by EV-D68 and most of them were immunocompetent (72.7%). Pneumonia was diagnosed in 12 (54.5%) children. Phylogenetic analysis of the VP1 region showed that all the strains identified in this study belonged to clade B3. Within B3 subclade, the Italian EV-D68 strains were most closely related to strains detected in Southern China in 2015 as well as to strains detected in US and the Netherlands in 2016. CONCLUSIONS: These results showed that EV-D68 infections are a common cause of lower respiratory illness in pediatric age. The circulation of one EV-D68 lineage has been proven in Italy and in the European region during 2016. However, further studies are required to investigate whether some strains or lineages may possess a higher affinity for the lower airway or central nervous system.
has issue date	2018-01-12(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2018.01.005
bibo:pmid	29396353
has license	no-cc
sha1sum (hex)	0079559ab8717d83bc3df6be8533ff9672bb4367
schema:url	https://doi.org/10.1016/j.jcv.2018.01.005
resource representing a document's title	Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy
has PubMed Central identifier	PMC7185653
has PubMed identifier	29396353
schema:publication	J Clin Virol
resource representing a document's body	covid:0079559ab8717d83bc3df6be8533ff9672bb4367#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0079559ab8717d83bc3df6be8533ff9672bb4367
is schema:about of	named entity 'circulation' named entity 'ENTEROVIRUS' named entity 'ITALY' named entity 'CIRCULATION' named entity 'D68' named entity 'NEW' named entity 'RESPIRATORY INFECTION' named entity 'PEDIATRIC' named entity 'CLADE' named entity 'PATIENTS' named entity 'SLAC' named entity 'clade' named entity 'asthma' named entity 'EV-D68' named entity 'Homo sapiens' named entity 'clades' named entity 'RSV' named entity 'QIAGEN' named entity 'EV-D68' named entity 'Italy' named entity 'EV-D68' named entity 'Hilden' named entity 'clade' named entity 'Milan' named entity 'Emergency Room' named entity 'clade' named entity 'clades' named entity 'amino acid' named entity 'Italy' named entity 'gene' named entity 'acute flaccid paralysis' named entity '2014 and 2015' named entity 'EV-D68' named entity 'viruses' named entity 'VP1' named entity 'EV-D68' named entity 'genome sequences' named entity 'SLAC' named entity 'clades' named entity 'Intensive Care Unit' named entity 'hRV' named entity 'diffusion' named entity 'evolutionary origin' named entity 'EV-D68' named entity 'human coronavirus' named entity 'Codon' named entity 'EV-D68' named entity 'infectious agent' named entity 'molecular phylogeny' named entity 'clade' named entity 'EV-D68' named entity 'EV-D68' named entity 'infection' named entity 'epidemiological' named entity 'β-sheets' named entity 'EV-D68' named entity 'Netherlands' named entity 'patients' named entity 'clade' named entity 'nucleotide substitution' named entity 'maximum likelihood' named entity 'amino acid' named entity 'Japan' named entity 'codons' named entity 'neurological problems' named entity 'EV-D68' named entity 'clades' named entity 'informed consent'

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