About: Increased pulmonary secretion of tumor necrosis factor-α in calves experimentally infected with bovine respiratory syncytial virus

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About: Increased pulmonary secretion of tumor necrosis factor-α in calves experimentally infected with bovine respiratory syncytial virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased pulmonary secretion of tumor necrosis factor-α in calves experimentally infected with bovine respiratory syncytial virus
Creator	Alexandersen, S Viuff, B Larsen, L Godson, D Rùnsholt, L Rùntved, C Tjùrnehùj, K
Source	Elsevier; Medline; PMC
abstract	Bovine respiratory syncytial virus (BRSV) is an important cause of respiratory disease among calves in the Danish cattle industry. An experimental BRSV infection model was used to study the pathogenesis of the disease in calves. Broncho alveolar lung lavage (BAL) was performed on 28 Jersey calves, of which 23 were experimentally infected with BRSV and five were given a mock inoculum. The presence of the cytokine tumor necrosis factor α (TNF-α) in the BAL fluids was detected and quantified by a capture ELISA. TNF-α was detected in 21 of the infected animals. The amount of TNF-α in the BAL fluid of calves killed post inoculation day (PID) 2 and 4 was at the same very low level as in the uninfected control animals. Large amounts of TNF-α were detected on PID 6, maximum levels of TNF-α were reached on PID 7, and smaller amounts of TNF-α were seen on PID 8. The high levels of TNF-α appeared on the days where severe lung lesions and clinical signs were obvious and the amounts of BRSV-antigen were at their greatest. Although Pasteurellaceae were isolated from some of the BRSV-infected calves, calves treated with antibiotics before and through the whole period of the infection, as well as BRSV-infected calves free of bacteria reached the same level of TNF-α as animals from which bacteria were isolated from the lungs. It is concluded that significant quantities of TNF-α are produced in the lungs of the calves on PID 6–7 of BRSV infection. The involvement of TNF-α in the pathogenesis of, as well as the anti-viral immune response against, BRSV infection is discussed.
has issue date	2000-10-31(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(00)00214-2
bibo:pmid	11044554
has license	no-cc
sha1sum (hex)	0110eaeb5103ac1d44cc2e7aa0f6c0f621e6acc7
schema:url	https://doi.org/10.1016/s0165-2427%2800%2900214-2
resource representing a document's title	Increased pulmonary secretion of tumor necrosis factor-α in calves experimentally infected with bovine respiratory syncytial virus
has PubMed Central identifier	PMC7119796
has PubMed identifier	11044554
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:0110eaeb5103ac1d44cc2e7aa0f6c0f621e6acc7#body_text
is schema:about of	named entity 'infection' named entity 'lung' named entity 'experimentally' named entity 'levels' named entity 'antibiotics' named entity 'study' named entity 'detected' named entity 'days' named entity 'detected' named entity 'TNF-a' named entity 'SECRETION' named entity 'VETERINARY IMMUNOLOGY' named entity 'BRSV' named entity 'IMPORTANT' named entity 'INCREASED' named entity 'BRONCHO ALVEOLAR' named entity 'FACTOR A' named entity 'USED' named entity 'CATTLE INDUSTRY' named entity 'POST' named entity 'CAPTURE' named entity 'ISOLATED' named entity 'PASTEURELLACEAE' named entity 'DETECTED' named entity 'INOCULATION' named entity 'SMALLER' named entity 'TUMOR NECROSIS FACTOR ' named entity 'CALVES' named entity 'PATHOGENESIS' named entity 'PID' named entity 'MAXIMUM' named entity 'EXPERIMENTAL' named entity 'ANTIBIOTICS' named entity 'LUNG' named entity 'DANISH' named entity 'GREATEST' named entity 'JERSEY' named entity 'PERIOD' named entity 'BAL' named entity 'UNINFECTED' named entity 'INFECTED' named entity 'TUMOR NECROSIS FACTOR' named entity 'BOVINE RESPIRATORY SYNCYTIAL VIRUS' named entity 'PULMONARY' named entity 'DISEASE' named entity 'STUDY' named entity 'PRESENCE OF' named entity 'PERFORMED' named entity 'VERY LOW LEVEL' named entity 'SEVERE' named entity 'KILLED' named entity 'LEVEL' named entity 'CAUSE' named entity 'ELISA' named entity 'IMMUNOPATHOLOGY' named entity 'CYTOKINE ' named entity 'WHERE' named entity 'ANTIGEN' named entity 'DAYS' named entity 'INFECTED' named entity 'MOCK' named entity 'QUANTITIES' named entity 'GIVEN' named entity 'AMOUNTS' named entity 'LESIONS' named entity 'INFECTION MODEL' named entity 'ANIMALS' named entity 'LUNG LAVAGE' named entity 'SEEN' named entity 'BOVINE RESPIRATORY SYNCYTIAL VIRUS' named entity 'INOCULUM' named entity 'BACTERIA ' named entity 'CONTROL' named entity 'HIGH' named entity 'TNF-A'

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