About: The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells

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About: The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells
Creator	Thiel, Volker Dijkman, Ronald Herrler, Georg Baumgärtner, Wolfgang Yang, Wei Beineke, Andreas Meng, Fandan Matrosovich, Mikhail Valentin-Weigand, Peter Wu, Nai-Huei
Source	Medline; PMC
abstract	Virus-host interactions in the respiratory epithelium during long term influenza virus infection are not well characterized. Therefore, we developed an air-liquid interface culture system for differentiated porcine respiratory epithelial cells to study the effect of virus-induced cellular damage. In our well-differentiated cells, α2,6-linked sialic acid is predominantly expressed on the apical surface and the basal cells mainly express α2,3-linked sialic acid. During the whole infection period, release of infectious virus was maintained at a high titre for more than seven days. The infected epithelial cells were subject to apoptosis resulting in the loss of ciliated cells together with a thinner thickness. Nevertheless, the airway epithelium maintained trans-epithelial electrical resistance and retained its barrier function. The loss of ciliated cells was compensated by the cells which contained the KRT5 basal cell marker but were not yet differentiated into ciliated cells. These specialized cells showed an increase of α2,3-linked sialic acid on the apical surface. In sum, our results help to explain the localized infection of the airway epithelium by influenza viruses. The impairment of mucociliary clearance in the epithelial cells provides an explanation why prior viral infection renders the host more susceptible to secondary co-infection by another pathogen.
has issue date	2016-12-22(xsd:dateTime)
bibo:doi	10.1038/srep39668
bibo:pmid	28004801
has license	cc-by
sha1sum (hex)	02843e9be924677d6541e0221a26501ce2111aaa
schema:url	https://doi.org/10.1038/srep39668
resource representing a document's title	The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells
has PubMed Central identifier	PMC5177954
has PubMed identifier	28004801
schema:publication	Sci Rep
resource representing a document's body	covid:02843e9be924677d6541e0221a26501ce2111aaa#body_text
is schema:about of	named entity 'interactions' named entity 'infected' covid:arg/02843e9be924677d6541e0221a26501ce2111aaa named entity 'virus' named entity 'cellular' named entity 'cells' named entity 'ciliated cells' named entity 'Therefore' named entity 'apical surface' named entity 'influenza' named entity 'infection' named entity 'culture system' named entity 'ciliated cells' named entity 'infection' named entity 'electrical resistance' named entity 'long term' named entity 'Virus' named entity 'sialic acid' named entity 'ciliated cells' named entity 'mucus' named entity 'H1N1' named entity 'growth medium' named entity 'bacterial pathogen' named entity 'antibody' named entity 'DMEM' named entity 'recombinant' named entity 'basal cells' named entity 'infection' named entity 'respiratory tract' named entity 'infection' named entity 'swine' named entity 'antibody' named entity 'sialic acids' named entity 'agglutinin' named entity 'infection' named entity 'haemagglutinin' named entity 'staining' named entity 'actin' named entity 'antibody' named entity 'secondary antibody' named entity 'lectins' named entity 'ciliated epithelium' named entity 'epithelial cells' named entity 'epoxy resin' named entity 'Statistical analysis' named entity 'histological examination' named entity 'apical surface' named entity 'long term' named entity 'ciliated cells' named entity 'respiratory epithelium' named entity 'IAV' named entity 'Herford' named entity 'infection' named entity 'caspase-3' named entity 'sialic acid' named entity 'PBS' named entity 'influenza A virus' named entity 'porcine' named entity 'co-infection' named entity 'trachea' named entity 'co-infection' named entity 'osmium tetroxide' named entity 'antibody' named entity 'Cy3' named entity 'serum' named entity 'tubulin' named entity 'infection' named entity 'epithelial cells' named entity 'defence mechanism' named entity 'lectins' named entity 'influenza A virus' named entity 'virus'

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