About: MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA
Creator	Matsuura, Yoshiharu Terada, Yutaka Kamitani, Wataru Kawachi, Kengo
topic	covid:03b2ac9edc6434f159edfa30e82673c94469f3ea#this
Source	Elsevier; Medline; PMC
abstract	MERS-CoV is the only lethal human CoV still endemic in the Arabian Peninsula and neither vaccine nor therapeutics against MERS-CoV infection is available. The nsp1 of CoV is thought to be a major virulence factor because it suppresses protein synthesis through the degradation of host mRNA. In contrast, viral RNA circumvents the nsp1-mediated translational shutoff for an efficient propagation. In this study, we identified amino acid residue in MERS-CoV nsp1 that differ from those of SARS-CoV nsp1, and that appear to be crucial for circumventing the translational shutoff. In addition, reverse genetics analysis suggested the presence of a cis-acting element at the 5′-terminus of the nsp1-coding region, which contributes to the specific recognition of viral RNA that is required for an efficient viral replication. Our results suggest the CoVs share a common mechanism for circumventing the nsp1-mediated translational shutoff.
has issue date	2017-08-23(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.08.026
bibo:pmid	28843094
has license	no-cc
sha1sum (hex)	03b2ac9edc6434f159edfa30e82673c94469f3ea
schema:url	https://doi.org/10.1016/j.virol.2017.08.026
resource representing a document's title	MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA
has PubMed Central identifier	PMC7118922
has PubMed identifier	28843094
schema:publication	Virology
resource representing a document's body	covid:03b2ac9edc6434f159edfa30e82673c94469f3ea#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/03b2ac9edc6434f159edfa30e82673c94469f3ea
is schema:about of	named entity 'Our' named entity 'MERS-CoV' named entity 'MERS CORONAVIRUS' named entity 'EFFICIENT' named entity 'OUR' named entity 'CODING REGION' named entity 'SARS-COV' named entity 'A MAJOR' named entity 'STUDY' named entity 'A COMMON' named entity 'HUMAN' named entity 'VIRULENCE FACTOR' named entity 'RECOGNITION' named entity 'SUPPRESSES' named entity 'ENDEMIC' named entity 'MRNA' named entity 'IDENTIFIED' named entity 'VIRAL REPLICATION' named entity 'MECHANISM' named entity 'LETHAL' named entity 'MEDIATED' named entity 'THOUGHT' named entity 'INFECTION' named entity 'REQUIRED' named entity 'RESULTS' named entity 'SHARE' covid:arg/03b2ac9edc6434f159edfa30e82673c94469f3ea named entity 'INTERACTION' named entity 'PROPAGATION' named entity 'NSP1' named entity 'NEITHER' named entity 'VIRAL RNA' named entity 'VIRAL RNA' named entity 'VACCINE' named entity 'TRANSLATIONAL' named entity 'ARABIAN PENINSULA' named entity 'PRESENCE OF' named entity 'SPECIFIC' named entity 'ANALYSIS' named entity 'PROTEIN SYNTHESIS' named entity 'THERAPEUTICS' named entity 'PROPAGATION' named entity 'SUGGEST' named entity 'DEGRADATION' named entity 'ELEMENT' named entity 'MERS-COV' named entity 'TERMINUS' named entity 'APPEAR' named entity 'ADDITION' named entity 'COVS' named entity 'REVERSE GENETICS' named entity 'AMINO ACID RESIDUE' named entity 'CONTRAST' named entity 'HOST' named entity '80%' named entity 'SPECIFIC' named entity 'AVAILABLE' named entity 'NSP1' named entity 'EFFICIENT' named entity 'mechanism' named entity 'amino acid' named entity 'therapeutics' named entity 'infection' named entity 'Arabian Peninsula' named entity 'MERS-CoV' named entity 'amino acid residue' named entity 'MERS-CoV' named entity 'virulence factor' named entity 'SARS-CoV' named entity 'viral RNA' named entity 'Western blot' named entity 'virus' named entity 'viral RNA' named entity 'polyadenylated' named entity 'Applied Biosystems' named entity 'GAPDH'

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