About: Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host

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About: Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host
Creator	Vodovotz, Yoram Bernabò, Nicola Murugesan, Ram Ahmed, Shiek Kumar, Vishal Paramasivam, Prabu Raj, Kamal Ramakrishnan, V Salehzadeh-Yazdi, Ali
Source	Medline; PMC
abstract	We dissect the mechanism of SARS-CoV-2 in human lung host from the initial phase of receptor binding to viral replication machinery. Two independent lung protein interactome were constructed to reveal the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis of virus. Further, we test the functional role of the hubs derived from the interactome. Most hubs proteins were differentially regulated on SARS-CoV-2 infection. Also, the proteins in viral replication hubs were related with cardiovascular disease, diabetes and hypertension confirming the vulnerability and severity of infection in the risk individual. Additionally, the hub proteins were closely linked with other viral infection, including MERS and HCoVs which suggest similar infection pattern in SARS-CoV-2. We identified five hubs that interconnect both networks that show the preparation of optimal environment in the host for viral replication process upon receptor attachment. Interestingly, we propose that seven potential miRNAs, targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.3389/fphys.2020.00802
bibo:pmid	32695025
has license	cc-by
sha1sum (hex)	055f6fe678a36e38e9ea10e7ee6fdd7c9f9ec03b
schema:url	https://doi.org/10.3389/fphys.2020.00802
resource representing a document's title	Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host
has PubMed Central identifier	PMC7338756
has PubMed identifier	32695025
schema:publication	Front Physiol
resource representing a document's body	covid:055f6fe678a36e38e9ea10e7ee6fdd7c9f9ec03b#body_text
is schema:about of	named entity 'receptor' named entity 'mechanism' named entity 'infection' named entity 'hubs' named entity 'VIRAL REPLICATION' named entity 'REGULATED' named entity 'PHASE' named entity 'INDEPENDENT' named entity 'SARS-COV-2' named entity 'PROTEINS' named entity 'HUB' named entity 'PROCESS A' named entity 'SEVERITY' covid:arg/055f6fe678a36e38e9ea10e7ee6fdd7c9f9ec03b named entity 'MERS' named entity 'phase' named entity 'regulated' named entity 'miRNAs' named entity 'test' named entity 'functional' named entity 'machinery' named entity 'vulnerability' named entity 'dissect' named entity 'machinery' named entity 'signaling' named entity 'proteins' named entity 'protein' named entity 'Human' named entity 'SARS-CoV-2' named entity 'hypertension' named entity 'receptor binding' named entity 'infection' named entity 'viral replication' named entity 'Cross Talk' named entity 'Receptor Binding' named entity 'diabetes' named entity 'text mining' named entity 'miRNA' named entity 'surface receptor' named entity 'miRNAs' named entity 'SARS-CoV-2' named entity 'single-stranded RNA' named entity 'protein' named entity 'SARS-CoV2' named entity 'nucleocapsid' named entity 'replication process' named entity 'SARS-CoV2' named entity 'nucleocapsid' named entity 'seed' named entity 'cardiovascular disease' named entity 'nucleocapsid' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'small molecules' named entity 'viral protein' named entity 'lung diseases' named entity 'protein' named entity 'data-mining' named entity 'protein' named entity 'hypertension' named entity 'non-structural proteins' named entity 'virus' named entity 'SARS-CoV-2' named entity 'protein interaction network' named entity 'PIF1' named entity 'structural proteins' named entity 'homeostasis' named entity 'miRNAs' named entity 'SARS-CoV2' named entity 'SARS' named entity 'SARS-CoV-2' named entity 'hypertension' named entity 'viral replication' named entity 'viral replication'

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