About: Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells

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About: Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells
Creator	Dijkman, Ronald Stalder, Hanspeter Kelly, Jenna Portmann, Jasmine Holwerda, Melle Laloli, Laura Stürmer, Isabel
topic	covid:05a52fe28de83b331a2625473d6eabe95af62cc7#this
Source	Medline; PMC
abstract	Influenza viruses are notorious pathogens that frequently cross the species barrier with often severe consequences for both animal and human health. In 2011, a novel member of the Orthomyxoviridae family, Influenza D virus (IDV), was identified in the respiratory tract of swine. Epidemiological surveys revealed that IDV is distributed worldwide among livestock and that IDV-directed antibodies are detected in humans with occupational exposure to livestock. To identify the transmission capability of IDV to humans, we determined the viral replication kinetics and cell tropism using an in vitro respiratory epithelium model of humans. The inoculation of IDV revealed efficient replication kinetics and apical progeny virus release at different body temperatures. Intriguingly, the replication characteristics of IDV revealed higher replication kinetics compared to Influenza C virus, despite sharing the cell tropism preference for ciliated cells. Collectively, these results might indicate why IDV-directed antibodies are detected among humans with occupational exposure to livestock.
has issue date	2019-04-24(xsd:dateTime)
bibo:doi	10.3390/v11040377
bibo:pmid	31022887
has license	cc-by
sha1sum (hex)	05a52fe28de83b331a2625473d6eabe95af62cc7
schema:url	https://doi.org/10.3390/v11040377
resource representing a document's title	Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells
has PubMed Central identifier	PMC6521319
has PubMed identifier	31022887
schema:publication	Viruses
resource representing a document's body	covid:05a52fe28de83b331a2625473d6eabe95af62cc7#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/05a52fe28de83b331a2625473d6eabe95af62cc7
is schema:about of	named entity 'IDV' named entity 'species barrier' named entity 'Cells' named entity 'WHY' named entity 'INFLUENZA VIRUSES' named entity 'CHARACTERISTICS' named entity 'CAPABILITY' named entity 'INFLUENZA C VIRUS' named entity 'RESPIRATORY TRACT' named entity 'SPECIES' named entity 'MODEL OF' named entity 'SWINE' named entity 'HUMAN' named entity 'PRIMARY' named entity 'TROPISM' named entity 'INFLUENZA D VIRUS' named entity 'CROSS' named entity 'BODY TEMPERATURES' named entity 'REPLICATION' named entity 'TRANSMISSION' named entity 'EXPOSURE TO' named entity 'OCCUPATIONAL EXPOSURE' named entity 'EPITHELIAL CELLS' named entity 'CELLULAR TROPISM' named entity 'INFLUENZA D VIRUS' named entity 'DIRECTED' named entity 'ANIMAL' named entity 'EFFICIENT' named entity 'SEVERE' named entity 'RESULTS' named entity 'EPIDEMIOLOGICAL' named entity 'PATHOGENS' named entity 'HIGHER' named entity 'THESE' named entity 'VIRUS RELEASE' named entity 'PREFERENCE' named entity 'ANTIBODIES' named entity 'USING' named entity 'TO IDENTIFY' named entity 'IN VITRO' named entity 'KINETICS' named entity 'LIVESTOCK' named entity 'CONSEQUENCES' named entity 'CELL' named entity 'NOVEL' named entity 'RESPIRATORY EPITHELIUM' named entity '2011' named entity 'HUMAN HEALTH' named entity 'COMPARED' named entity 'SURVEYS' named entity 'BARRIER' named entity 'MEMBER OF' named entity 'PROGENY' named entity 'HUMANS' named entity 'IDV' named entity 'DETERMINED' named entity 'DISTRIBUTED' named entity 'FREQUENTLY' named entity 'CILIATED CELLS' named entity 'APICAL' named entity 'WORLDWIDE' named entity 'IDENTIFIED' named entity 'DETECTED' named entity 'DIFFERENT' named entity 'WELL-DIFFERENTIATED' named entity 'REPLICATION' named entity 'KINETICS' named entity 'AIRWAY' named entity 'SHARING' named entity 'ORTHOMYXOVIRIDAE' named entity 'INOCULATION' named entity 'REVEALED' named entity 'FAMILY'

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