About: Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi)

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About: Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi)
Creator	Zhang, Jing Gestier, Sarah Gu, Xingnian Hall, Jane Jenkins, Cheryl Parrish, Kate Rose, Karrie Srivastava, Mukesh Finlaison, Deborah Frost 1☯, Melinda Kirkland, Peter Read, Andrew
source	Medline; PMC
abstract	In mid-February 2015, a large number of deaths were observed in the sole extant population of an endangered species of freshwater snapping turtle, Myuchelys georgesi, in a coastal river in New South Wales, Australia. Mortalities continued for approximately 7 weeks and affected mostly adult animals. More than 400 dead or dying animals were observed and population surveys conducted after the outbreak had ceased indicated that only a very small proportion of the population had survived, severely threatening the viability of the wild population. At necropsy, animals were in poor body condition, had bilateral swollen eyelids and some animals had tan foci on the skin of the ventral thighs. Histological examination revealed peri-orbital, splenic and nephric inflammation and necrosis. A virus was isolated in cell culture from a range of tissues. Nucleic acid sequencing of the virus isolate has identified the entire genome and indicates that this is a novel nidovirus that has a low level of nucleotide similarity to recognised nidoviruses. Its closest relatives are nidoviruses that have recently been described in pythons and lizards, usually in association with respiratory disease. In contrast, in the affected turtles, the most significant pathological changes were in the kidneys. Real time PCR assays developed to detect this virus demonstrated very high virus loads in affected tissues. In situ hybridisation studies confirmed the presence of viral nucleic acid in tissues in association with pathological changes. Collectively these data suggest that this virus is the likely cause of the mortalities that now threaten the survival of this species. Bellinger River Virus is the name proposed for this new virus.
has issue date	2018-10-24(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0205209
bibo:pmid	30356240
has license	cc-by
sha1sum (hex)	05c54da3a4bd3e92c4d0e5286e331e333408c9a9
schema:url	https://doi.org/10.1371/journal.pone.0205209
resource representing a document's title	Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi)
has PubMed Central identifier	PMC6200216
has PubMed identifier	30356240
schema:publication	PLoS One
resource representing a document's body	covid:05c54da3a4bd3e92c4d0e5286e331e333408c9a9#body_text
is schema:about of	named entity 'POTENTIAL' named entity 'cell culture' named entity '2015' named entity 'virus' named entity 'MORTALITIES' named entity 'SPECIES' named entity 'BILATERAL' named entity 'SEVERELY' named entity 'KIDNEYS' named entity 'MOST SIGNIFICANT' named entity 'CONTINUED' named entity 'ENTIRE' named entity 'CAUSE' named entity 'ADULT' named entity 'BELLINGER RIVER VIRUS' named entity 'PATHOLOGICAL' named entity 'PERI' named entity 'NEW SOUTH WALES' named entity 'ENDANGERED SPECIES' named entity 'CONTRAST' named entity 'NEW' named entity 'LIKELY' named entity 'NOVEL' named entity 'RECENTLY' named entity 'VERY SMALL' named entity 'SIMILARITY' named entity 'SNAPPING TURTLE' named entity 'CEASED' named entity 'RESPIRATORY DISEASE' named entity 'VENTRAL' named entity 'DEAD' named entity 'NECROSIS' named entity 'PYTHONS' named entity 'APPROXIMATELY' named entity 'IDENTIFICATION' named entity '7 WEEKS' named entity 'CONFIRMED' named entity 'BODY CONDITION' named entity 'MORE THAN' named entity 'SKIN' named entity 'ENDANGERED' named entity 'SNAPPING TURTLE' named entity 'NOVEL' named entity 'LARGE SCALE' named entity 'SPLENIC' named entity 'FEBRUARY' named entity 'STUDIES' named entity 'TAN' named entity 'REAL TIME PCR' named entity 'RIVER' named entity 'EXTANT' named entity '400' named entity 'FOCI' named entity 'SOLE' named entity 'IS A' named entity 'AUSTRALIA' named entity 'COASTAL' named entity '2015' named entity 'CHANGES' named entity 'NUMBER OF DEATHS' named entity 'TURTLES' named entity 'IN SITU HYBRIDISATION' named entity 'OUTBREAK' named entity 'ORBITAL' named entity 'INFLAMMATION' named entity 'LARGE' named entity 'WILD' named entity 'SURVIVAL' named entity 'CELL CULTURE' named entity 'ISOLATE'

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