About: Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients

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About: Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients
Creator	Xu, Bin Guan, Ming Wang, Xuan Hu, Xiu-Ping Ou, Xue-Ting Weng, Xin-Hua Wu, Ji-Qin Zhu, Li-Ping
source	PMC
abstract	Background. There is increasing evidence that mannose-binding lectin (MBL) has a complex role in many diseases, particularly in infectious diseases. However, the relationship between MBL deficiency and cryptococcal meningitis has not been clarified. The purpose of this study was to investigate the correlation between MBL polymorphism and non-HIV cryptococcal meningitis. Methods. A case-controlled genetic association study was conducted. Patients with cryptococcal meningitis and control subjects were genotyped for 6 alleles of MBL2 gene (H/L, Y/X, P/Q, A/D, A/B, and A/C). The distributions in allele frequency, genotypes, haplotypes, and genotype groups were compared between patients and control subjects. Results. Study participants included 103 HIV-uninfected patients with cryptococcal meningitis and 208 healthy control subjects, all of Chinese Han ethnicity. The homozygous mutative genotypes (O/O) of the coding region were associated with cryptococcal meningitis (P = .023; odds ratio [OR], 4.29; 95% confidence interval [CI], 1.11–19.88), the correlation more overt in immunocompetent patients (P = .005; OR, 6.65; 95% CI, 1.49–33.05). MBL-deficient participant group was associated with cryptococcal meningitis (P = .039; OR, 2.09; 95% CI, .96–4.51), particularly in immunocompetent patients (P = .028; OR, 2.51; 95% CI, .96–6.22). Conclusions. This is the first to show genotypes coding for MBL deficiency are associated with cryptococcal meningitis in nonimmunocompromised hosts.
has issue date	2011-06-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jir152
bibo:pmid	21592999
has license	no-cc
sha1sum (hex)	063b4d952f36a0563968fae7c0467a6adabdc66c
schema:url	https://doi.org/10.1093/infdis/jir152
resource representing a document's title	Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients
has PubMed Central identifier	PMC7107303
has PubMed identifier	21592999
schema:publication	J Infect Dis
resource representing a document's body	covid:063b4d952f36a0563968fae7c0467a6adabdc66c#body_text
is schema:about of	named entity 'MBL' named entity 'study' covid:arg/063b4d952f36a0563968fae7c0467a6adabdc66c named entity 'CORRELATION' named entity 'CLARIFIED' named entity 'CRYPTOCOCCAL MENINGITIS' named entity 'BACKGROUND' named entity 'CHINESE' named entity 'RELATIONSHIP' named entity 'MBL DEFICIENCY' named entity 'NON-' named entity 'COMPLEX' named entity 'HIV' named entity 'ROLE' named entity 'POLYMORPHISM' named entity 'GENOTYPES' named entity 'HIV' named entity 'CRYPTOCOCCAL MENINGITIS' named entity 'PATIENTS' named entity 'UNINFECTED' named entity 'CORRELATED' named entity 'MANNOSE-BINDING LECTIN DEFICIENCY' named entity 'CODING' named entity 'INFECTIOUS DISEASES' named entity 'EVIDENCE' named entity 'STUDY' named entity 'MANNOSE-BINDING LECTIN' named entity 'TO INVESTIGATE' named entity 'DISEASES' named entity 'MBL' named entity 'PURPOSE' named entity 'INCREASING' named entity 'correlation' named entity 'HIV' named entity 'MBL' named entity 'cryptococcal meningitis' named entity 'cryptococcal meningitis' named entity 'MBL' named entity 'MBL' named entity 'bioMérieux' named entity 'MBL2' named entity 'antisense' named entity 'MBL' named entity 'gene polymorphism' named entity 'MBL' named entity '95% CI' named entity 'mutants' named entity 'PCR' named entity 'cryptococcal meningitis' named entity 'histopathological' named entity 'Han ethnicity' named entity 'correlation' named entity 'genotypes' named entity 'CSF' named entity 'haplotype' named entity 'MBL deficiency' named entity 'protein' named entity 'lymphocytopenia' named entity 'MBL' named entity 'ng/mL' named entity 'CD4' named entity '95% CI' named entity 'complement pathway' named entity 'primers' named entity 'ng/mL' named entity 'MBL' named entity 'diabetes mellitus' named entity 'CSF' named entity 'immunosuppressive medications' named entity 'ng/mL' named entity 'genotypes' named entity 'MBL' named entity 'SNPs' named entity 'MBL'

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