About: Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins
Creator	Mukhopadhyay, Suchetana Id, Jolene
source	Medline; PMC
abstract	For 30 years it was thought the alphavirus 6K gene encoded a single 6 kDa protein. However, through a bioinformatics search 10 years ago, it was discovered that there is a frameshifting event and two proteins, 6K and transframe (TF), are translated from the 6K gene. Thus, many functions attributed to the 6K protein needed reevaluation to determine if they properly belong to 6K, TF, or both proteins. In this mini-review, we reevaluate the past research on 6K and put those results in context where there are two proteins, 6K and TF, instead of one. Additionally, we discuss the most cogent outstanding questions for 6K and TF research, including their collective importance in alphavirus budding and their potential importance in disease based on the latest virulence data.
has issue date	2017-08-18(xsd:dateTime)
bibo:doi	10.3390/v9080228
bibo:pmid	28820485
has license	cc-by
sha1sum (hex)	069a3aebc920d5da476fef73fd5d47566c780885
schema:url	https://doi.org/10.3390/v9080228
resource representing a document's title	Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins
has PubMed Central identifier	PMC5580485
has PubMed identifier	28820485
schema:publication	Viruses
resource representing a document's body	covid:069a3aebc920d5da476fef73fd5d47566c780885#body_text
is schema:about of	named entity 'encoded' named entity 'Frames' named entity 'ALPHAVIRUS' named entity 'ENCODED' named entity 'THOUGHT' named entity 'STATE' named entity 'SINGLE' named entity 'PROTEINS' named entity 'VIRUSES' named entity 'FRAMES' named entity 'YEARS' named entity '6 KDA PROTEIN' named entity 'ALPHAVIRUS' named entity 'RESEARCH' named entity 'GENE' named entity 'For' named entity 'gene' named entity 'protein' named entity 'protein' named entity 'host cells' named entity 'morphology' named entity 'protein' named entity 'Follow-up studies' named entity 'lumen' named entity 'permeability' named entity 'recombination' named entity 'cell culture' named entity 'amino acid residues' named entity 'Colombia' named entity 'virions' named entity 'clone' named entity 'M2 protein' named entity 'coronavirus' named entity 'alphaviruses' named entity 'morbidity' named entity 'arthropod' named entity 'animal models' named entity 'life cycle' named entity 'polyprotein' named entity 'frameshifting' named entity 'cytoplasm' named entity 'assembly and budding' named entity 'RRV' named entity 'palmitoylated' named entity 'glycoproteins' named entity 'complement' named entity 'protein' named entity 'gene' named entity 'SINV' named entity 'polyprotein' named entity 'nucleocapsid' named entity 'SINV' named entity 'lumen' named entity 'phenotypes' named entity 'vaccination' named entity 'cell membranes' named entity 'palmitoylated' named entity 'open reading frames' named entity 'cytosolic' named entity 'protein' named entity 'SINV' named entity 'protein' named entity 'infection' named entity 'chimera' named entity 'open reading frame' named entity 'phenotypes' named entity 'nucleotide' named entity 'protein' named entity 'CHIKV' named entity 'phenotype' named entity 'acylation' named entity 'alphavirus' named entity 'protein products' named entity 'hydrophobic' named entity 'virulence' named entity 'luciferase' named entity 'potassium chloride' named entity 'eukaryotic cells' named entity 'glycoprotein' named entity 'glycoproteins'

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