About: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

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About: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Creator	Lima, Marcelo Skidmore, Mark Yates, Edwin Fernig, David Guerrini, Marco Guimond, Miller, Gavin Mycroft-West, Courtney Turnbull, Jeremy
Source	BioRxiv; MedRxiv
abstract	Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulfate to regulate homeostasis and use heparan sulfate as a means to adhere and gain access to cells. Moreover, mucosal epithelia such as that of the respiratory tract are protected by a layer of mucin polysaccharides, which are usually sulfated. Consequently, the polydisperse, natural products of heparan sulfate and the allied polysaccharide, heparin have been found to be involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1. Here we use surface plasmon resonance and circular dichroism to measure the interaction between the SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) and heparin. The data demonstrate an interaction between the recombinant surface receptor binding domain and the polysaccharide. This has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals.
has issue date	2020-03-02(xsd:dateTime)
bibo:doi	10.1101/2020.02.29.971093
has license	medrxiv
sha1sum (hex)	07e833d0917cace550853f72923856d0fe1a7120
schema:url	https://doi.org/10.1101/2020.02.29.971093
resource representing a document's title	The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
schema:publication	bioRxiv
resource representing a document's body	covid:07e833d0917cace550853f72923856d0fe1a7120#body_text
is schema:about of	named entity 'development' named entity 'recombinant' named entity 'surface' named entity 'RBD' named entity 'RUNNING TITLE' named entity 'HEPARIN' covid:arg/07e833d0917cace550853f72923856d0fe1a7120 named entity 'HSR1' named entity 'HAVE' named entity 'HOMEOSTASIS' named entity 'SPIKE' named entity 'SARS-COV-2' named entity 'RECEPTOR BINDING' named entity 'WEST' named entity 'CORONAVIRUS' named entity 'CIRCULAR DICHROISM' named entity 'POLYDISPERSE' named entity 'HERE' named entity 'DATA' named entity 'DOMAIN' named entity 'BASED' named entity 'RAPID' named entity 'TAILOR' named entity 'THERAPEUTIC' named entity 'HUNDREDS' named entity 'MUCOSAL' named entity 'DEVELOPMENT' named entity 'ADVANTAGE' named entity 'PREVENT' named entity 'INVOLVED' named entity 'PROTEIN ' named entity 'BINDS' named entity 'POLYSACCHARIDE' named entity 'RESPIRATORY TRACT' named entity 'TO REGULATE' named entity 'ANTIVIRALS' named entity 'USE' named entity 'GLYCOSAMINOGLYCANS' named entity 'NATURAL PRODUCTS' named entity 'SURFACE' named entity 'HEPARIN BINDING' named entity 'CONFORMATIONAL CHANGE' named entity 'RANGE' named entity 'LAYER' named entity 'GAG' named entity 'ACCESS' named entity 'EXTRACELLULAR PROTEINS' named entity 'HEPARAN SULFATE' named entity 'POLYSACCHARIDES' named entity 'INTERACTION' named entity 'SARS-COV-2' named entity 'HOST' named entity 'ADHERE' named entity 'CELLS' named entity 'SURFACE PLASMON RESONANCE' named entity 'MEANS' named entity 'VIRUSES' named entity 'RECOMBINANT' named entity 'MUCIN' named entity 'INCLUDING' named entity 'SURFACE' named entity 'CORONAVIRUS' named entity 'HEPARIN' named entity 'DEPENDENCE' named entity 'TO MEASURE' named entity 'INFECTION' named entity 'FOUND' named entity '2019' named entity 'ASSOCIATED' named entity 'GAIN' named entity 'RBD' named entity 'LINE' named entity 'PATHOGENS' named entity 'STRAIN' named entity 'GENERATION' named entity 'RECEPTOR BINDING'

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