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About:
Immunostimulants in respiratory diseases: focus on Pidotimod
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An Entity of Type :
schema:ScholarlyArticle
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Immunostimulants in respiratory diseases: focus on Pidotimod
Creator
Alves-Correia, Magna
Giorgis, Veronica
Heffler, Enrico
Mager, Riccardo
Marinoni, Massimiliano
Melioli, Giovanni
Mohamed, Manar-Farouk
Paoletti, Giovanni
Puggioni, Francesca
Racca, Francesca
Stomeo, Niccolò
Varricchi, Gilda
Canonica, Giorgio
Source
Medline; PMC
abstract
Usefulness of Pidotimod and its role as immunostimulant, has been discussed, we know, for several decades. Nevertheless, there is still much to know. Understanding its mechanisms and its potential usefulness in airway infections and its prevention, asthma both Th2 and non Th2 type, bronchiectasis, as adjuvant in vaccination and in allergen immunotherapy still remains to clearly unveil. The aim of this paper was to provide a useful updated review of the role of the main available immunostimulants, giving particular focus on Pidotimod use and its potentials utility in respiratory diseases. Pidotimod showed its usefulness in reducing need for antibiotics in airway infections, increasing the level of immunoglobulins (IgA, IgM, IgG) and T-lymphocyte subsets (CD3+, CD4+) endowed with immunomodulatory activity that affect both innate and adaptive immune responses. Higher expression of TLR2 and of HLA-DR molecules, induction of dendritic cell maturation and release of pro-inflammatory molecules, stimulation of T lymphocyte proliferation and differentiation toward a Th1 phenotype, as well as an increase of the phagocytosis have been demonstrated to be associated with Pidotimod in in vitro studies. All these activities are potentially useful for several respiratory conditions such as asthma, COPD, and recurrent respiratory tract infections.
has issue date
2019-11-04
(
xsd:dateTime
)
bibo:doi
10.1186/s40248-019-0195-2
bibo:pmid
31700623
has license
cc-by
sha1sum (hex)
088207699688d96fe973df88c1add87ac8339645
schema:url
https://doi.org/10.1186/s40248-019-0195-2
resource representing a document's title
Immunostimulants in respiratory diseases: focus on Pidotimod
has PubMed Central identifier
PMC6827234
has PubMed identifier
31700623
schema:publication
Multidiscip Respir Med
resource representing a document's body
covid:088207699688d96fe973df88c1add87ac8339645#body_text
is
schema:about
of
named entity 'potential'
named entity 'infections'
named entity 'All'
named entity 'respiratory conditions'
named entity 'adjuvant'
named entity 'IgG'
named entity 'subsets'
named entity 'IgA'
named entity 'FOCUS'
named entity 'REVIEW OF'
named entity 'ITS'
named entity 'ASSOCIATED WITH'
named entity 'AIM'
named entity 'TO PROVIDE'
named entity 'ANTIBIOTICS'
named entity 'PARTICULAR'
named entity 'PHAGOCYTOSIS'
named entity 'USEFULNESS'
named entity 'INFLAMMATORY'
named entity 'BRONCHIECTASIS'
named entity 'NEED FOR'
named entity 'HAVE'
named entity 'PAPER'
named entity 'UPDATED'
named entity 'IMMUNOSTIMULANT'
named entity 'PRO-'
named entity 'MAIN'
named entity 'DENDRITIC CELL MATURATION'
named entity 'COPD'
named entity 'EXPRESSION'
named entity 'REDUCING'
named entity 'VACCINATION'
named entity 'T LYMPHOCYTE PROLIFERATION'
named entity 'IMMUNOSTIMULANTS'
named entity 'ADAPTIVE IMMUNE RESPONSES'
named entity 'TYPE'
named entity 'IGG'
named entity 'IMMUNOMODULATORY ACTIVITY'
named entity 'HIGHER'
named entity 'MOLECULES'
named entity 'INFECTIONS'
named entity 'TLR2'
named entity 'RESPIRATORY DISEASES'
named entity 'RESPIRATORY'
named entity 'INCREASING'
named entity 'INDUCTION'
named entity 'IMMUNOGLOBULINS'
named entity 'ACTIVITIES'
named entity 'CD4'
named entity 'DIFFERENTIATION'
named entity 'PIDOTIMOD'
named entity 'INCREASE'
named entity 'IGM'
named entity 'T-LYMPHOCYTE SUBSETS'
named entity 'RESPIRATORY DISEASES'
named entity 'I E'
named entity 'ACCESS'
named entity 'IMMUNOSTIMULANTS'
named entity 'ROLE'
named entity 'ASTHMA'
named entity 'USEFUL'
named entity 'UTILITY'
named entity 'NON'
named entity 'MECHANISMS'
named entity 'RELEASE'
named entity 'MUCH'
named entity 'IN VITRO STUDIES'
named entity 'UNDERSTANDING'
named entity 'AIRWAY'
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