About: Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials

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About: Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials
Creator	Bruska, Małgorzata Dompe, Claudia Gutaj, Paweł Hutchings, Greg Janowicz, Krzysztof Kempisty, Bartosz Moncrieff, Lisa Mozdziak, Paul Nowicki, Michał Ożegowska, Katarzyna Pieńkowski, Wojciech Piotrowska-Kempisty, Hanna Popis, Małgorzata Prado, Shibli, Jamil Stefańska, Katarzyna Walterson, Mathias Zabel, Maciej
Source	Medline; PMC
abstract	Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due to their self-renewal and differentiation capacity. Although embryonic stem cells are pluripotent, their utilization involves embryo destruction and is ethically controversial. Therefore, adult tissues that have emerged as an alternative source of stem cells and perinatal tissues, such as the umbilical cord, appear to be particularly attractive. Wharton’s jelly, a gelatinous connective tissue contained in the umbilical cord, is abundant in mesenchymal stem cells (MSCs) that express CD105, CD73, CD90, Oct-4, Sox-2, and Nanog among others, and have the ability to differentiate into osteogenic, adipogenic, chondrogenic, and other lineages. Moreover, Wharton’s jelly-derived MSCs (WJ-MSCs) do not express MHC-II and exhibit immunomodulatory properties, which makes them a good alternative for allogeneic and xenogeneic transplantations in cellular therapies. Therefore, umbilical cord, especially Wharton’s jelly, is a promising source of mesenchymal stem cells.
has issue date	2020-04-12(xsd:dateTime)
bibo:doi	10.3390/jcm9041102
bibo:pmid	32290584
has license	cc-by
sha1sum (hex)	088e020bf7522d792b7be9a4efd51e91e41bcc10
schema:url	https://doi.org/10.3390/jcm9041102
resource representing a document's title	Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials
has PubMed Central identifier	PMC7230974
has PubMed identifier	32290584
schema:publication	J Clin Med
resource representing a document's body	covid:088e020bf7522d792b7be9a4efd51e91e41bcc10#body_text
is schema:about of	named entity 'embryo' named entity 'differentiation' named entity 'Clinical Trials' named entity 'Specificity' named entity 'Models' named entity 'NANOG' named entity 'PERINATAL' named entity 'MESENCHYMAL STEM CELLS' named entity 'DO NOT' named entity 'EXPRESS' named entity 'EXHIBIT' named entity 'ATTRACTIVE' named entity 'ADULT' named entity 'CD73' named entity 'Wharton' named entity 'capacity' named entity 'express' named entity 'stem cells' named entity 'utilization' named entity 'Oct-4' named entity 'MSCs' named entity 'MSCs' named entity 'ethically' named entity 'connective tissue' named entity 'gelatinous' named entity 'Therefore' named entity 'allogeneic' named entity 'regenerative' named entity 'umbilical cord' named entity 'promising' named entity 'adipogenic' named entity 'immunomodulatory' named entity 'embryo destruction' named entity 'umbilical cord' named entity 'CD90' named entity 'stem cells' named entity 'CD73' named entity 'Clinical Medicine' named entity 'Animal Models' named entity 'mouse model' named entity 'umbilical cord' named entity 'Immunohistochemical staining' named entity 'ST-elevation' named entity 'Parkinson's disease' named entity 'mouse model' named entity 'myofibroblasts' named entity 'myogenic' named entity 'Transforming growth factor' named entity 'intrathecally' named entity 'xenogeneic' named entity 'intermediate filament protein' named entity 'cytolytic' named entity 'co-cultured' named entity 'gestation' named entity 'immunomodulatory' named entity 'carbon tetrachloride' named entity 'cell lines' named entity 'self-renewal' named entity 'connective tissue' named entity 'actin' named entity 'stem cells' named entity 'explant' named entity 'MSCs' named entity 'HLA-DR'

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