About: Disease modelling in human organoids

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Disease modelling in human organoids
Creator	Huch, Meritxell Lancaster, Madeline
Source	PMC
abstract	The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programmes, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This article and accompanying poster highlight the currently available methods, particularly those aimed at modelling human biology, and provide an overview of their capabilities and limitations. We also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.
has issue date	2019-07-01(xsd:dateTime)
bibo:doi	10.1242/dmm.039347
bibo:pmid	31383635
has license	cc-by
sha1sum (hex)	0a4df0b92940218a7fc69cb46ba22c8f83a5bb9f
schema:url	https://doi.org/10.1242/dmm.039347
resource representing a document's title	Disease modelling in human organoids
has PubMed Central identifier	PMC6679380
has PubMed identifier	31383635
schema:publication	Dis Model Mech
resource representing a document's body	covid:0a4df0b92940218a7fc69cb46ba22c8f83a5bb9f#body_text
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