About: Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis

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About: Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis
Creator	Buonomo, Erica Carey, Maureen Cowardin, Carrie Naylor, Caitlin Noor, Zannatun Wills-Karp, Marsha Burgess, Stacey Petri, William Cowardin, Carey Petri, Sl, Burgess Wills-Karp M, Noor
topic	covid:0afa3ea846396533c7ca515968abcfea3f895082#this
Source	PMC
abstract	There is an emerging paradigm that the human microbiome is central to many aspects of health and may have a role in preventing enteric infection. Entamoeba histolytica is a major cause of amebic diarrhea in developing countries. It colonizes the colon lumen in close proximity to the gut microbiota. Interestingly, not all individuals are equally susceptible to E. histolytica infection. Therefore, as the microbiota is highly variable within individuals, we sought to determine if a component of the microbiota could regulate susceptibility to infection. In studies utilizing a murine model, we demonstrated that colonization of the gut with the commensal Clostridia-related bacteria known as segmented filamentous bacteria (SFB) is protective during E. histolytica infection. SFB colonization in this model was associated with elevated cecal levels of interleukin 17A (IL-17A), dendritic cells, and neutrophils. Bone marrow-derived dendritic cells (BMDCs) from SFB-colonized mice had higher levels of IL-23 production in response to stimulation with trophozoites. Adoptive transfer of BMDCs from an SFB(+) to an SFB(−) mouse was sufficient to provide protection against E. histolytica. IL-17A induction during BMDC transfer was necessary for this protection. This work demonstrates that intestinal colonization with a specific commensal bacterium can provide protection during amebiasis in a murine model. Most importantly, this work demonstrates that the microbiome can mediate protection against an enteric infection via extraintestinal effects on bone marrow-derived dendritic cells.
has issue date	2014-11-04(xsd:dateTime)
bibo:doi	10.1128/mbio.01817-14
bibo:pmid	25370489
has license	cc-by-nc-sa
sha1sum (hex)	0afa3ea846396533c7ca515968abcfea3f895082
schema:url	https://doi.org/10.1128/mbio.01817-14
resource representing a document's title	Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis
has PubMed Central identifier	PMC4222101
has PubMed identifier	25370489
schema:publication	mBio
resource representing a document's body	covid:0afa3ea846396533c7ca515968abcfea3f895082#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0afa3ea846396533c7ca515968abcfea3f895082
is schema:about of	named entity 'paradigm' named entity 'SFB' named entity 'colon' named entity 'preventing' named entity 'levels' named entity 'colonization' named entity 'COLITIS' named entity 'ALTERED MICROBIOTA' named entity 'MICE' named entity 'TO PROVIDE' named entity 'ADOPTIVE TRANSFER' named entity 'CLOSE' named entity 'MODEL' named entity 'SEGMENTED FILAMENTOUS BACTERIA' named entity 'PARADIGM' named entity 'E. HISTOLYTICA' named entity 'DIARRHEA' named entity 'STIMULATION' named entity 'ENTAMOEBA HISTOLYTICA' named entity 'ASSOCIATED WITH' named entity 'KNOWN' named entity 'CLOSTRIDIA' named entity 'AMEBIC' named entity 'SFB' named entity 'MURINE' named entity 'MICROBIOTA' named entity 'COLON LUMEN' named entity 'MOUSE' named entity 'CECAL' named entity 'MICE' named entity 'THE GUT' named entity 'GUT MICROBIOTA' named entity 'VARIABLE' named entity 'ENTAMOEBA HISTOLYTICA' named entity 'DENDRITIC CELLS' named entity 'DEPENDENT' named entity 'BONE MARROW' named entity 'DETERMINE' named entity 'RESPONSE TO' named entity 'MAY HAVE' named entity 'INTERLEUKIN 17A' named entity 'PROTECTION' named entity 'PROTECTION' named entity 'SUSCEPTIBILITY TO INFECTION' named entity 'IL-23 PRODUCTION' named entity 'LEVELS' named entity 'DEMONSTRATED' named entity 'ROLE' named entity 'INFECTION' named entity 'SUSCEPTIBLE' named entity 'ELEVATED' named entity 'TRANSFER' named entity 'COMPONENT' named entity 'A MAJOR' named entity 'DERIVED' named entity 'DENDRITIC CELLS' named entity 'TROPHOZOITES' named entity 'BACTERIA ' named entity 'RELATED' named entity 'PREVENTING' named entity 'IL-17A' named entity 'HIGHLY' named entity 'STUDIES' named entity 'SUFFICIENT' named entity 'COMMENSAL' named entity 'PROXIMITY' named entity 'CENTRAL' named entity 'PROVIDE'

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