About: Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations

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About: Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations
Creator	Tello-Ruiz, Edgar Weiner, David Chokkalingam, Neethu Kulp, Daniel Walker, Susanne Xu, Ziyang
source	Elsevier; Medline; PMC
abstract	CD4+ T cells play an important role in the maturation of the antibody responses. Conjugation of identified CD4+ T cell helper epitope to the target antigen has been developed as a strategy to enhance vaccine-induced humoral immunity. In this work, we reported the identification of a novel HLA-IAb helper epitope LS-3 from Aquifex aeolicus. In silico analysis predicted this epitope to have high binding affinity to common human HLA alleles and have complementary binding coverage to the established PADRE epitope. Introduction of HLA-IAb knockout mutations to the LS-3 epitope significantly attenuated humoral responses induced by a vaccine containing this epitope. Finally, engineered fusion of the epitope to a model antigen, influenza hemagglutinin, significantly improved both binding and hemagglutination inhibition antibody responses in mice receiving DNA or protein vaccines. In summary, LS-3 and additional identified CD4+ helper epitopes may be further explored to improve vaccine responses in translational studies.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1016/j.isci.2020.101399
bibo:pmid	32763137
has license	no-cc
sha1sum (hex)	0bef096e1eb42bbec0f865c06392f12728b90a46
schema:url	https://doi.org/10.1016/j.isci.2020.101399
resource representing a document's title	Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations
has PubMed Central identifier	PMC7409978
has PubMed identifier	32763137
schema:publication	iScience
resource representing a document's body	covid:0bef096e1eb42bbec0f865c06392f12728b90a46#body_text
is schema:about of	named entity 'Novel' named entity 'Identified' named entity 'CD4+' named entity 'Vaccinations' named entity 'size exclusion chromatography' named entity 'CD4' named entity 'intramuscular injections' named entity 'HLA-DR' named entity 'leader sequence' named entity 'microtiter plates' named entity 'mice' named entity 'epitope' named entity 'vaccine' named entity 'antigen' named entity 'CD4+' named entity 'epitopes' named entity 'animal studies' named entity 'antibody' named entity 'H1N1' named entity 'percentile rank' named entity 'CD44+' named entity 'RNA' named entity 'transgene' named entity 'immunodominant' named entity 'peptides' named entity 'CD4+ T cell' named entity 'protein sequences' named entity 'protein domains' named entity 'adaptive immune responses' named entity 'CD3e' named entity 'epitope' named entity 'humoral responses' named entity 'nickel' named entity 'antibody' named entity 'allele' named entity 'HLA-DRB1' named entity 'mutation' named entity 'murine' named entity 'MHC-II' named entity 'antigen' named entity 'epitopes' named entity 'pro-inflammatory cytokines' named entity 'epitopes' named entity 'attenuation' named entity 'C-terminal' named entity 'C57BL/6' named entity 'Light Scattering' named entity 'HLA-DR' named entity 'antibody' named entity 'CD4' named entity 'peptide' named entity 'carrier proteins' named entity 'cloned' named entity 'mice' named entity 'CD4+' named entity 'DLna' named entity 'cytokine' named entity 'immunodominant' named entity 'murine' named entity 'binding affinity' named entity 'nanoparticle' named entity 'CD4+ T cell' named entity 'murine' named entity 'HIV-1' named entity 'SEC' named entity 'IFNγ' named entity 'HLA' named entity 'GE Healthcare' named entity 'IgG' named entity 'immunological synapses' named entity 'antibody' named entity 'HLA' named entity 'codon' named entity 'binding antibody' named entity 'protein domains' named entity 'mice'

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