About: The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3

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About: The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3
Creator	Ruzsics, Zsolt Greber, Urs Hemmi, Silvio Schaffner, Walter Sirena, Dominique
source	Elsevier; Medline; PMC
abstract	Abstract Human adenovirus (Ad) serotype 3 causes respiratory infections. It is considered highly virulent, accounting for about 13% of all Ad isolates. We report here the complete Ad3 DNA sequence of 35,343 base pairs (GenBank accession DQ086466). Ad3 shares 96.43% nucleotide identity with Ad7, another virulent subspecies B1 serotype, and 82.56 and 62.75% identity with the less virulent species B2 Ad11 and species C Ad5, respectively. The genomic organization of Ad3 is similar to the other human Ads comprising five early transcription units, E1A, E1B, E2, E3, and E4, two delayed early units IX and IVa2, and the major late unit, in total 39 putative and 7 hypothetical open reading frames. A recombinant E1-deleted Ad3 was generated on a bacterial artificial chromosome. This prototypic virus efficiently transduced CD46-positive rodent and human cells. Our results will help in clarifying the biology and pathology of adenoviruses and enhance therapeutic applications of viral vectors in clinical settings.
has issue date	2005-12-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2005.08.024
bibo:pmid	16169033
has license	els-covid
sha1sum (hex)	0c3be9775e24a07931a5644899df5c99636895be
schema:url	https://doi.org/10.1016/j.virol.2005.08.024
resource representing a document's title	The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3
has PubMed Central identifier	PMC7172737
has PubMed identifier	16169033
schema:publication	Virology
resource representing a document's body	covid:0c3be9775e24a07931a5644899df5c99636895be#body_text
is schema:about of	named entity 'AD5' named entity 'ADS' named entity 'E1B' named entity 'CLINICAL SETTINGS' named entity 'LESS VIRULENT' named entity 'kDa' named entity 'genomes' named entity 'TATA-like box' named entity 'Ad5' named entity 'kDa' named entity 'protein' named entity 'eGFP' named entity 'restriction enzymes' named entity 'signal sequences' named entity 'respiratory illness' named entity 'kDa' named entity 'Ad5' named entity 'therapeutic applications' named entity 'open reading frames' named entity 'subspecies' named entity 'GenBank' named entity 'adenovirus' named entity 'virulent' named entity 'vector' named entity 'nucleotide sequence' named entity 'hexon' named entity 'viral DNA' named entity 'nucleotides' named entity 'TATA box' named entity 'DNA polymerase' named entity 'lysine' named entity 'Ad5' named entity 'ORF' named entity 'hexon' named entity 'eGFP' named entity 'sequence analysis' named entity 'transfection' named entity 'receptor' named entity 'motif' named entity 'phosphoglycerate kinase' named entity 'agnoprotein' named entity 'subcloned' named entity 'restriction sites' named entity 'open reading frames' named entity 'serotypes' named entity 'transiently transfected' named entity 'protein' named entity 'highly conserved' named entity 'eGFP' named entity 'zinc-binding' named entity 'E1B proteins' named entity 'mRNA' named entity 'recombinant' named entity 'expression cassette' named entity 'dendritic cells' named entity 'plasmids' named entity 'cleavage site' named entity 'calcium phosphate' named entity 'Invitrogen' named entity 'genome' named entity 'phosphoprotein' named entity 'protein' named entity 'protein' named entity 'Invitrogen' named entity 'protein' named entity 'kDa' named entity 'Ad5' named entity 'carboxy-terminal' named entity 'homologue' named entity 'eGFP' named entity 'viruses' named entity 'kDa' named entity 'phage lambda' named entity 'C-terminal' named entity 'Stratagene' named entity 'protease' named entity 'hematopoietic cell'

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