About: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures

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About: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures
Creator	O'horo, John Barnathan, Elliot Khan, Najat Puranik, Arjun Soundararajan, Venky Venkatakrishnan, A Wagner, Tyler Badley, Andrew Halamka, John Morice Ii, William Murugadoss, Karthik Pawlowski, Colin Houghton, Damon Loscalzo, Liam Makimura, Hideo Pruthi, Rajiv
Source	MedRxiv
abstract	Temporal inference from laboratory testing results and their triangulation with clinical outcomes as described in the associated unstructured text from the provider notes in the Electronic Health Record (EHR) is integral to advancing precision medicine. Here, we studied 181 COVIDpos and 7,775 COVIDneg patients subjected to 1.3 million laboratory tests across 194 assays during a two-month observation period centered around their SARS-CoV-2 PCR testing dates. We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. However, these measures show opposite longitudinal trends as the infection evolves, with declining fibrinogen and increasing platelet counts to levels that are lower and higher compared to the COVIDneg cohort, respectively. Our EHR augmented curation efforts suggest a minority of patients develop thromboembolic events after the PCR testing date, including rare cases with disseminated intravascular coagulopathy (DIC), with most patients lacking the platelet reductions typically observed in consumptive coagulopathies. These temporal trends present, for the first time, fine-grained resolution of COVID-19 associated coagulopathy (CAC), via a digital framework that synthesizes longitudinal lab measurements with structured medication data and neural network-powered extraction of outcomes from the unstructured EHR. This study demonstrates how a precision medicine platform can help contextualize each patients specific coagulation profile over time, towards the goal of informing better personalization of thromboprophylaxis regimen.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1101/2020.05.21.20109439
has license	medrxiv
sha1sum (hex)	0c833e6358e1de50f066779933904705767fc917
schema:url	https://doi.org/10.1101/2020.05.21.20109439
resource representing a document's title	Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures
resource representing a document's body	covid:0c833e6358e1de50f066779933904705767fc917#body_text
is schema:about of	named entity 'extraction' named entity 'personalization' named entity 'patients' named entity 'levels' named entity 'counts' named entity 'Longitudinal' named entity 'laboratory testing' named entity 'DATE' named entity 'COAGULOPATHIES' named entity 'PRECISION MEDICINE' named entity 'REDUCTIONS' named entity 'UNSTRUCTURED' named entity 'COHORTS' named entity 'PLATFORM' named entity 'LAB' named entity 'LONGITUDINAL' named entity 'NEURAL NETWORK' named entity 'STUDY' named entity 'MEDICATION' named entity '1.3' named entity 'precision medicine' named entity 'platform' named entity 'neural' named entity 'specific' named entity 'testing' named entity 'evolves' named entity 'time' named entity 'declining' named entity 'counts' named entity 'cohort' named entity 'compared' named entity 'diagnostic testing' named entity 'patient' named entity 'structured' named entity 'coagulation' named entity 'observed' named entity 'plasma' named entity 'COVID' named entity 'coagulopathy' named entity 'EHR' named entity 'thromboembolic events' named entity 'coagulopathy' named entity 'COVID-19' named entity 'PCR' named entity 'Temporal' named entity 'study' named entity 'effect size' named entity 'COVID' named entity 'blood loss' named entity 'D-dimer' named entity 'Thrombosis' named entity 'coagulation' named entity 'clinical outcomes' named entity 'medRxiv' named entity 'p-values' named entity 'Yes/No' named entity 'sample size' named entity 'platelet count' named entity 'thrombotic' named entity 'coagulation' named entity 'thrombotic' named entity 'phenotypes' named entity 'platelet' named entity 'thromboses' named entity 'COVID-19' named entity 'D-dimers' named entity 'medRxiv' named entity 'platelet counts' named entity 'medRxiv' named entity 'effect size'

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