About: Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis

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About: Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis
Creator	Li, Lei Germain, Devon Godbout, Roseline Hildebrandt, Matthew Hughes, Sarah Simmonds, Andrew
source	Elsevier; Medline; PMC
abstract	Abstract Mammalian DDX1 has been implicated in RNA trafficking, DNA double-strand break repair and RNA processing; however, little is known about its role during animal development. Here, we report phenotypes associated with a null Ddx1 (Ddx1 AX ) mutation generated in Drosophila melanogaster. Ddx1 null flies are viable but significantly smaller than control and Ddx1 heterozygous flies. Female Ddx1 null flies have reduced fertility with egg chambers undergoing autophagy, whereas males are sterile due to disrupted spermatogenesis. Comparative RNA sequencing of control and Ddx1 null third instars identified several transcripts affected by Ddx1 inactivation. One of these, Sirup mRNA, was previously shown to be overexpressed under starvation conditions and implicated in mitochondrial function. We demonstrate that Sirup is a direct binding target of Ddx1 and that Sirup mRNA is differentially spliced in the presence or absence of Ddx1. Combining Ddx1 null mutation with Sirup dsRNA-mediated knock-down causes epistatic lethality not observed in either single mutant. Our data suggest a role for Drosophila Ddx1 in stress-induced regulation of splicing.
has issue date	2015-11-15(xsd:dateTime)
bibo:doi	10.1016/j.ydbio.2015.09.012
bibo:pmid	26433063
has license	els-covid
sha1sum (hex)	0d27ee4e776e49e383933f6560dbbf67158d0a3f
schema:url	https://doi.org/10.1016/j.ydbio.2015.09.012
resource representing a document's title	Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis
has PubMed Central identifier	PMC7094483
has PubMed identifier	26433063
schema:publication	Developmental Biology
resource representing a document's body	covid:0d27ee4e776e49e383933f6560dbbf67158d0a3f#body_text
is schema:about of	named entity 'DDX1' named entity 'double-strand break repair' named entity 'viable' named entity 'RNA' named entity 'KNOWN' named entity 'ROLE' named entity 'EPISTATIC' named entity 'HETEROZYGOUS' named entity 'OUR' named entity 'NOT OBSERVED' named entity 'TARGET' named entity 'DIRECT BINDING' named entity 'DDX1' named entity 'ABSENCE OF' named entity 'VIABLE' named entity 'ABOUT' named entity 'PRESENCE' named entity 'MUTATION' named entity 'ASSOCIATED WITH' named entity 'MRNA' named entity 'THESE' named entity 'EGG' named entity 'COMBINING' named entity 'REDUCED FERTILITY' named entity 'SPLICED' named entity 'FLIES' named entity 'IDENTIFIED' named entity 'DISRUPTED' named entity 'STERILE' named entity 'INDUCED' named entity 'DUE TO' covid:arg/0d27ee4e776e49e383933f6560dbbf67158d0a3f named entity 'PROTEIN ' named entity 'GAMETOGENESIS' named entity 'LEADS' named entity 'BUT' named entity 'DNA DOUBLE-STRAND BREAK REPAIR' named entity 'AFFECTED' named entity 'DROSOPHILA' named entity 'MALES' named entity 'TRAFFICKING' named entity 'AUTOPHAGY' named entity 'CONDITIONS' named entity 'STRESS' named entity 'REGULATION OF SPLICING' named entity 'HERE' named entity 'SIRUP' named entity 'REPORT' named entity 'MUTANT' named entity 'NULL MUTATION' named entity 'MITOCHONDRIAL FUNCTION' named entity 'TRANSCRIPTS' named entity 'ONE OF' named entity 'PREVIOUSLY' named entity 'MAMMALIAN' named entity 'CHAMBERS' named entity 'DROSOPHILA MELANOGASTER' named entity 'DEAD BOX PROTEIN' named entity 'MEDIATED' named entity 'SUGGEST' named entity 'SMALLER' named entity 'IS A' named entity 'FEMALE' named entity 'GENERATED' named entity 'RNA SEQUENCING' named entity 'CAUSES' named entity 'EITHER' named entity 'KNOCK-DOWN' named entity 'STARVATION' named entity 'PHENOTYPES' named entity 'ITS' named entity 'HAVE' named entity 'LITTLE' named entity 'DROSOPHILA MELANOGASTER' named entity 'CONTROL' named entity 'LOSS OF'

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