About: Microbes, Helminths and Rheumatic Diseases

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Microbes, Helminths and Rheumatic Diseases
Creator	Carolina, Ana Fonseca, João Airton, Francisco Dinelly Pinto, Matias Duarte-Monteiro, Ana Fonseca, Henrique Da Mota, Henrique Da Mota, Ana Licia, Maria Margarida Duarte-Monteiro, Ana Matias, Dinelly Pinto, João Rocha, Castro
source	Elsevier; Medline; PMC
abstract	There has been a progressive interest on the modifications of the human defense system following insults occurring in the interface between our body and the external environment, as they may provoke or worsen disease states. Studies suggest the billions of germs that compose the gut microbiota influence one’s innate and adaptive immune responses at the intestinal level, but these microorganisms may also impact rheumatic diseases. The microbiota of the skin, respiratory and urinary tracts may also be relevant in rheumatology. Evidence indicates that changes in the gut microbiome alter the pathogenesis of immune-mediated diseases such as rheumatoid arthritis and ankylosing spondylitis but also of other disorders like atherosclerosis and osteoarthritis. Therapeutic strategies to modify the microbiota, including probiotics and fecal microbiota transplantation, have been received with skepticism, which, in turn, has drawn attention back to previously developed interventions such as antibiotics. Helminths adapted to humans over the evolution process, but their role in disease modulation, particularly immune-mediated diseases, remains to be understood. The present review focuses on data concerning modifications of the immune system induced by interactions with microbes and pluricellular organisms, namely helminths, and their impact on rheumatic diseases. Practical aspects, including specific microbiota-targeted therapies, are also discussed.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1016/j.berh.2020.101528
bibo:pmid	32448639
has license	no-cc
sha1sum (hex)	0d3abfdabae8d2242d957306c3995b1812086b2c
schema:url	https://doi.org/10.1016/j.berh.2020.101528
resource representing a document's title	Microbes, Helminths and Rheumatic Diseases
has PubMed Central identifier	PMC7203059
has PubMed identifier	32448639
schema:publication	Best Pract Res Clin Rheumatol
resource representing a document's body	covid:0d3abfdabae8d2242d957306c3995b1812086b2c#body_text
is schema:about of	named entity 'immune-mediated' named entity 'rheumatology' named entity 'diseases' named entity 'pathogenesis' named entity 'microbes' named entity 'external' named entity 'helminths' named entity 'induced' named entity 'organisms' named entity 'Rheumatic' named entity 'Rheumatic' named entity 'LEVEL' named entity 'STUDIES' named entity 'STATES' named entity 'INTERFACE' named entity 'ATHEROSCLEROSIS' named entity 'PATHOGENESIS' named entity 'ORGANISMS' named entity 'RESPIRATORY' named entity 'DISEASE' named entity 'ANKYLOSING SPONDYLITIS' named entity 'URINARY' named entity 'MICROBIOTA' named entity '27S' named entity 'REMAINS' named entity 'INTERACTIONS' named entity 'EXTERNAL' named entity 'RHEUMATOID ARTHRITIS' named entity 'SYSTEM' named entity 'PROBIOTICS' named entity 'rheumatic diseases' named entity 'adaptive immune responses' named entity 'Studies' named entity 'modulation' named entity 'adapted' named entity 'system' named entity 'immune-mediated' named entity 'adaptive immune responses' named entity 'rheumatology' named entity 'microbiota' named entity 'fecal microbiota transplantation' named entity 'microbiota' named entity 'Helminths' named entity 'germs' named entity 'pathogenesis' named entity 'Rheumatic Diseases' named entity 'type 2' named entity 'arthropathies' named entity 'antiviral' named entity 'antibiotic' named entity 'peptides' named entity 'inflammation' named entity 'developing countries' named entity 'rheumatic diseases' named entity 'Gold salts' named entity 'microbiome' named entity 'arthritis' named entity 'intracellular signal transduction' named entity 'Antibiotics' named entity 'fat tissue' named entity 'Helminths' named entity 'normal flora' named entity 'high-quality' named entity 'commensals' named entity 'macrophage' named entity 'infection' named entity 'urogenital tract' named entity 'tight junctions' named entity 'NFATc1'

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