About: Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line

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About: Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line
Creator	Yang, Deok-Chun Kim, Jong Kang, Jong Arunkumar, Lakshminarayanan Chan Ahn, Jong Han, Yaxi Jung, Seok-Kyu Kim, Mia Lee, Gyong Rupa, Esrat
Source	PMC
abstract	Dendropanax morbifera is a versatile plant that has been used as a herbal medicine due to its various useful medicinal effects. To protect its active component from biological stress and increase its drug efficacy as well as drug bioavailability, nanoemulsion was prepared. Dendropanax morbifera zinc oxide nanoparticles (DM-ZnO NPs) were synthesized using the plant extract via the co-precipitation method and loaded with active indole-3-carbinol for nanoemulsion formulation using the ultrasonication process. Field emission transmission electron microscope revealed the flower shape of the Dendropanax morbifera indole-3-carbinol zinc oxide nanoemulsion (DM-ZnO-I3C-NE). In contrast, DM-ZnO NPs showed a spheroid shape that coincides agreeably with field emission electron scanning microscope. The hydrodynamic sizes by dynamic light scattering are about 65 ± 3 nm and 239.6 ± 6 nm and the crystallite sizes from X-ray diffraction are 11.52 nm and 16.07 nm for DM-ZnO NPs and DM-ZnO-I3C-NE, respectively. In vitro analysis revealed the cytotoxicity of DM-ZnO-I3C-NE against a human lung cancer cell line (A549) at 12.5 µg/mL as well as reactive oxygen species (ROS) production. The DM-ZnO-I3C-NE-induced ROS generation level was higher than that of DM-ZnO NPs and free indole-3-carbinol. The synergistic effect of DM-ZnO and indole-3-carbinol indicates DM-ZnO-I3C-NE as a potential candidate for future lung cancer drug and could be scope for functional food.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.3390/ma13143197
bibo:pmid	32709058
has license	cc-by
sha1sum (hex)	0d483273787d023a32e8072f7d891b8c3698d916
schema:url	https://doi.org/10.3390/ma13143197
resource representing a document's title	Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line
has PubMed Central identifier	PMC7412136
has PubMed identifier	32709058
schema:publication	Materials (Basel)
resource representing a document's body	covid:0d483273787d023a32e8072f7d891b8c3698d916#body_text
is schema:about of	named entity 'human lung' named entity 'loaded' named entity 'In vitro' named entity 'ROS' named entity 'sizes' named entity 'materials' named entity 'Line' named entity 'Dendropanax' named entity 'nanoemulsion' named entity 'candidate' named entity 'functional food' named entity 'plant extract' named entity 'effects' named entity 'drug' named entity 'higher' named entity 'shape' named entity 'scanning microscope' named entity 'reactive oxygen species' named entity 'cytotoxicity' named entity 'zinc oxide' named entity 'crystallite' named entity 'X-ray diffraction' named entity 'Dendropanax' named entity 'Indole-3-Carbinol' named entity 'Field emission' named entity 'active ingredients' named entity 'ZnO' named entity 'co-precipitation' named entity 'petal' named entity 'plant extract' named entity 'diacetate' named entity 'zinc nitrate' named entity 'surfactant' named entity 'ZnO' named entity 'cell line' named entity 'I3C' named entity 'wurtzite structure' named entity 'human lung' named entity 'SEM' named entity 'Korea' named entity 'cell lines' named entity 'I3C' named entity 'streptomycin' named entity 'synergistic effect' named entity 'fluorescence' named entity 'Dendropanax' named entity 'I3C' named entity 'precipitation' named entity 'South Korea' named entity 'ZnO' named entity 'I3C' named entity 'field emission' named entity 'ROS' named entity 'DLS' named entity 'I3C' named entity 'nanoemulsion' named entity 'I3C' named entity 'amplitude' named entity 'nanoemulsion' named entity 'culture medium' named entity 'I3C' named entity 'nanoparticles' named entity 'A549' named entity 'ultrasonication' named entity 'I3C' named entity 'lung cancer' named entity 'anti-cancer' named entity 'olive oil' named entity 'flower' named entity 'Wando-gun' named entity 'broad peak' named entity '0.9'

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