About: Schinus terebenthifolius Raddi extracts: from sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant

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About: Schinus terebenthifolius Raddi extracts: from sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Schinus terebenthifolius Raddi extracts: from sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant
Creator	Oliveira, Santos Rocha, Santos Barros Valentim, Iara Bezerra, Mônika Borbely, Alexandre Borbely, Cruz Dos, Tauane Goulart, Fonseca Lopes, Eloiza Lourival, Melo Mota, Oliveira, Marília Pires, Nobre Santos, Jaqueline Silva, Keyla Steponavicius, Karen Tanabe, Lira Valentim, Iara
source	Elsevier; Medline; PMC
abstract	Abstract Schinus terebinthifolius Raddi is a well-known medicinal plant native of South America. This species has demonstrated important biological activities such as antihypertensive and vasodilator, antimicrobial, anti-inflammatory and antioxidant. However, no studies have been, so far, reported with the fruits of S. terebinthifolius as a protector of the placenta against Zika virus infection and as sunscreen agents. The present study aimed to investigate new uses for the ethanolic fruit extracts of S. terebinthifolius, from fruits’peel (STPE) and from the whole fruits (STWFE). Zika virus (ZIKV) has been linked to several fetal malformations, such as microcephaly and other central nervous system abnormalities. Thus, the potential of these natural extracts against ZIKV infection was evaluated, using an in vitro method. The photoprotective potential, determined by spectrometry, along with phenolic content, antioxidant capacity, and chemical composition of both extracts were also evaluated. The chemical composition of the extracts was evaluated by HPLC-UV / vis. The cytotoxicity of peel and whole fruit extracts in vero E6 cell lines, in placental cell lines and placental explant cultures were evaluated by the MTT assay. The infectivity of placental cells and explants was evaluated by qRT-PCR and the effects of extracts on ZIKV infection were investigated using HTR-8/SVneo cells, pre-treated with 100 μg mL-1 of STWFE for 1 h, and infected with MR766 (AD) or PE243 (EH) ZIKV strains. STFE and STWFE were well-tolerated by both placental-derived trophoblast cell line HTR-8/SVneo as well as by term placental chorionic villi explants, which indicate absence of cytotoxicity in all analysed concentrations. Two strains of ZIKV were tested to access if pre-treatment of trophoblast cells with the STWFE would protect them against infection. Flow cytometry analysis revealed that STWFE extract greatly reduced ZIKV infection. The extracts were also photoprotective with SPF values equivalent to the standard, benzophenone-3. The formulations prepared in different concentrations of the extracts (5-10%) had shown maximum SPF values of 32.21. STWFE represents a potential natural mixture to be used in pregnancy in order to restrain placental infection by ZIKV and might potentially protect fetus against ZIKV-related malformations. The extracts exhibited photoprotective activity and some of the phenolic compounds, mainly resveratrol, catechin and epicatechin, are active ingredients in all assayed activities. The development of biotechnological/medical products, giving extra value to products from family farming, is expected, with strong prospects for success.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1016/j.indcrop.2020.112503
bibo:pmid	32346222
has license	els-covid
sha1sum (hex)	0d81dfed14616501feaeb0a3e075f5c417905e2c
schema:url	https://doi.org/10.1016/j.indcrop.2020.112503
resource representing a document's title	Schinus terebenthifolius Raddi extracts: from sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant
has PubMed Central identifier	PMC7186214
has PubMed identifier	32346222
schema:publication	Ind Crops Prod
resource representing a document's body	covid:0d81dfed14616501feaeb0a3e075f5c417905e2c#body_text
is schema:about of	named entity 'medicinal plant' named entity 'inhibited' named entity 'Schinus' named entity 'Zika' named entity 'Schinus' named entity 'infection' named entity 'placenta' named entity 'Zika virus' named entity 'infection' named entity 'Brazil' named entity 'reactive oxygen' named entity 'bioactive' named entity 'pregnancy' named entity 'cytotrophoblast' named entity 'absorbance' named entity 'DMEM' named entity 'Trolox' named entity 'photoprotective' named entity 'ethanolic' named entity 'distilled water' named entity 'preventive measures' named entity 'L-glutamine' named entity 'leukocytes' named entity 'calibration curve' named entity 'photoprotective' named entity 'Vero E6' named entity 'antiviral' named entity 'photoprotective' named entity 'placenta' named entity 'pathogens' named entity 'photoprotection' named entity 'ethanolic' named entity 'trophoblast' named entity 'statistical analysis' named entity 'histological' named entity 'trophoblast' named entity 'erythema' named entity 'morphological' named entity 'placenta' named entity 'natural product' named entity 'seed' named entity 'photoprotective' named entity 'analysis of variance' named entity 'UVB' named entity 'anti-allergic' named entity 'antiproliferative' named entity 'absorbance' named entity 'sodium carbonate' named entity 'chemical constituents' named entity 'antimalarial' named entity 'chronic diseases' named entity 'photoprotective' named entity 'photoprotective' named entity 'antioxidant' named entity 'gallic acid' named entity 'Schinus terebinthifolius' named entity 'fetal bovine serum' named entity 'PBS' named entity 'culture medium' named entity 'UV absorption' named entity 'resveratrol' named entity 'molecular interactions' named entity 'infection' named entity 'rotary evaporator'

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