About: Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11
Creator	Zhao, Qi Cheng, Gregory Cheng, Man Cheung, Wing-Tai Chan, Paul Au, Shannon Chan, Ceci Cheung, Randy Ho, Walter Kamesh Bikkavilli, Rama Lee, Susanna
Source	Elsevier; Medline; PMC
abstract	Abstract Infection of SARS-associated coronavirus (SARS-CoV) induced a strong anti-nucleocapsid (anti-N) antibody response. However, the pathophysiological significance of the anti-N antibodies in SARS pathogenesis is largely unknown. To profile the anti-N antibodies, a phage-displayed scFv library was prepared from mice immunized with heat-inactivated SARS-CoV-infected Vero E6 cell lysate. Specific anti-N scFvs were isolated by panning against a recombinant nucleocapsid protein and reactivity was confirmed with phage-ELISA. Sequence analysis indicated that two of the isolated anti-N scFv clones were identical and displayed a high homology with an scFv specific for interleukin 11 (IL-11), an anti-inflammatory cytokine derived from bone marrow stroma cells. In a neutralization assay, IL-11-induced STAT 3 phosphorylation in rat intestinal epithelial IEC-18 cells was completely suppressed by the anti-N scFv clone L9N01.
has issue date	2005-12-23(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.10.088
bibo:pmid	16263078
has license	els-covid
sha1sum (hex)	0df4acedd15922e72eb97cc24fcc7c77f866aa11
schema:url	https://doi.org/10.1016/j.bbrc.2005.10.088
resource representing a document's title	Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11
has PubMed Central identifier	PMC7092895
has PubMed identifier	16263078
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:0df4acedd15922e72eb97cc24fcc7c77f866aa11#body_text
is schema:about of	named entity 'CROSS' named entity 'IL-11' named entity 'REACTIVITY' named entity 'PREPARED' named entity 'STRONG' named entity 'INFECTION' named entity 'INDUCED' named entity 'NUCLEOCAPSID PROTEIN' named entity 'COMPLETELY' named entity 'PHOSPHORYLATION' named entity 'RECOMBINANT' named entity 'RAT' named entity 'INACTIVATED' named entity 'ANTIBODY' named entity 'NUCLEOCAPSID PROTEIN' named entity 'CORONAVIRUS' named entity 'SARS' named entity 'ANTIBODY RESPONSE' named entity 'IL-11' named entity 'PROTEIN ' named entity 'INDICATED' named entity 'ISOLATED' named entity 'SARS' named entity 'PROTEIN ' named entity 'CLONE' named entity 'ANTI-INFLAMMATORY CYTOKINE' named entity 'HOMOLOGY' named entity 'CELLS' named entity 'SUPPRESSED' named entity 'ANTIBODIES' named entity 'HEAT' named entity 'IEC-18' named entity 'IMMUNIZED' named entity 'MICE' named entity 'SARS-COV' named entity 'LIBRARY' named entity 'IDENTICAL' named entity 'LARGELY' named entity 'ASSAY' named entity 'SIGNIFICANCE' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'HIGH' named entity 'PATHOGENESIS' named entity 'INFECTED' named entity 'SCFV' named entity 'PHAGE' named entity 'REACTIVITY' named entity 'CLONES' named entity 'BONE MARROW STROMA' named entity 'CELL LYSATE' named entity 'VERO E6 CELL' named entity 'SEQUENCE ANALYSIS' named entity 'PANNING' named entity 'ELISA' named entity 'DERIVED' named entity 'STAT' named entity 'CONFIRMED' named entity 'NUCLEOCAPSID' named entity 'SPECIFIC' named entity 'INTESTINAL' named entity 'EPITHELIAL' named entity 'PROFILE' named entity 'DISPLAYED' named entity 'UNKNOWN' named entity 'CYTOKINE ' named entity 'INTERLEUKIN 11' covid:arg/0df4acedd15922e72eb97cc24fcc7c77f866aa11 named entity 'SARS' named entity 'rat' named entity 'phage' named entity 'clones'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software