About: Respiratory and Blood Stream Infections are Associated with Subsequent Venous Thromboembolism After Primary Intracerebral Hemorrhage

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About: Respiratory and Blood Stream Infections are Associated with Subsequent Venous Thromboembolism After Primary Intracerebral Hemorrhage Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory and Blood Stream Infections are Associated with Subsequent Venous Thromboembolism After Primary Intracerebral Hemorrhage
Creator	Boehme, Amelia Claassen, Jan Elkind, Mitchell Ironside, Natasha Melmed, Kara Park, Soojin Agarwal, Sachin Murthy, Santosh Roh, David Connolly, E
source	PMC
abstract	BACKGROUND: Infection and venous thromboembolism (VTE) are associated with worse outcomes after intracerebral hemorrhage (ICH). The relationship between infection and VTE in ICH patients is unclear. We hypothesized that infection would be associated with subsequent VTE after ICH. METHODS: We retrospectively studied consecutively admitted spontaneous primary ICH patients from 2009 to 2018 surviving beyond 24 h. The primary predictor variable was infection, diagnosed prior to VTE. The primary outcome was VTE. We used multivariable logistic regression models to estimate the odds ratios and 95% confidence intervals (OR, 95% CI) for VTE risk after infection of any type, after adjusting for ICH score, length of stay and days to deep venous thrombosis (DVT) prophylaxis. Similar analysis was done to estimate the association of infection subtypes, including respiratory and urinary and blood stream infections (BSI) with VTE. RESULTS: There were 414 patients (mean age 65 years, 47% female) that met were analyzed. Infection was diagnosed in 181 (44%) patients. Incident VTE was diagnosed in 36 (9%) patients, largely comprised of DVT (n = 32; 89%). Infection overall was associated with increased risk of subsequent VTE (adjusted OR 4.5, 95% CI 1.6–12.6). Respiratory (adjusted OR 5.7, 95% CI 2.8–11.7) and BSI (adjusted OR 4.0, 95% CI 1.3–11.0) were associated with future VTE. Urinary and other infections were not associated with subsequent VTE. CONCLUSIONS: Infections are associated with subsequent risk of VTE among patients with ICH. Further investigation is required to elucidate mechanisms behind this association and to improve VTE prevention after ICH.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1007/s12028-020-00974-8
bibo:pmid	32385835
has license	no-cc
sha1sum (hex)	0e68f22cf671592e4f2cf128a5483c0c0597f572
schema:url	https://doi.org/10.1007/s12028-020-00974-8
resource representing a document's title	Respiratory and Blood Stream Infections are Associated with Subsequent Venous Thromboembolism After Primary Intracerebral Hemorrhage
has PubMed Central identifier	PMC7223996
has PubMed identifier	32385835
schema:publication	Neurocrit Care
resource representing a document's body	covid:0e68f22cf671592e4f2cf128a5483c0c0597f572#body_text
is schema:about of	named entity 'Thromboembolism' named entity 'Venous' named entity 'VENOUS THROMBOEMBOLISM' named entity 'VTE' named entity 'RELATIONSHIP' named entity 'infection' named entity 'VTE' named entity 'ICH' named entity 'intracerebral hemorrhage' named entity 'Venous Thromboembolism' named entity 'ICH' named entity 'infection' named entity 'Nosocomial infections' named entity 'attending physician' named entity 'Ventriculitis' named entity 'VTE' named entity 'antibiotics' named entity 'C. difficile' named entity 'intracerebral hemorrhage' named entity 'VTE' named entity 'DVT' named entity 'infection' named entity 'lavage' named entity 'bacteria' named entity 'infection' named entity '11.6' named entity 'NIH' named entity 'VTE' named entity 'VTE' named entity 'pulmonary embolism' named entity 'VTE' named entity 'markers of disease' named entity 'DVT' named entity 'DVT' named entity 'prophylaxis' named entity 'VTE' named entity 'infection' named entity '1.6' named entity 'hospital discharge' named entity 'hemorrhage' named entity 'infection' named entity 'VTE' named entity 'UTI' named entity 'bronchial' named entity 'pharmacologic' named entity 'VTE' named entity 'VTE' named entity 'oxygen' named entity 'pro-inflammatory' named entity 'GCS' named entity 'DVT' named entity 'malignancy' named entity 'not-for-profit' named entity 'endothelial dysfunction' named entity 'VTE' named entity 'treatment protocol' named entity 'VTE' named entity 'etiologies' named entity 'retrospective cohort study' named entity 'fibrinolysis' named entity 'nosocomial infections' named entity 'VTE' named entity 'infection' named entity 'DVT' named entity 'infection' named entity 'VTE' named entity 'inflammatory mediators' named entity 'prophylaxis' named entity 'KRM' named entity 'VTE' named entity 'infection' named entity 'fever'

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