About: The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis

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About: The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis
Creator	Openshaw, Peter Campbell, Harry Nair, Harish Falsey, Ann Wedzicha, Jadwiga Shi, Ting Arnott, Andrew Semogas, Indre
topic	covid:0e7881e97024fe722e03b821d76391d8361a8008#this
Source	Medline; PMC
abstract	Acute respiratory tract infections (ARI) constitute a substantial disease burden in adults and elderly individuals. We aimed to identify all case-control studies investigating the potential role of respiratory viruses in the etiology of ARI in older adults aged ≥65 years. We conducted a systematic literature review (across 7 databases) of case-control studies published from 1996 to 2017 that investigated the viral profile of older adults with and those without ARI. We then computed a pooled odds ratio (OR) with a 95% confidence interval and virus-specific attributable fraction among the exposed (AFE) for 8 common viruses: respiratory syncytial virus (RSV), influenza virus (Flu), parainfluenza virus (PIV), human metapneumovirus (HMPV), adenovirus (AdV), rhinovirus (RV), bocavirus (BoV), and coronavirus (CoV). From the 16 studies included, there was strong evidence of possible causal attribution for RSV (OR, 8.5 [95% CI, 3.9–18.5]; AFE, 88%), Flu (OR, 8.3 [95% CI, 4.4–15.9]; AFE, 88%), PIV (OR, not available; AFE, approximately 100%), HMPV (OR, 9.8 [95% CI, 2.3–41.0]; AFE, 90%), AdV (OR, not available; AFE, approximately 100%), RV (OR, 7.1 [95% CI, 3.7–13.6]; AFE, 86%) and CoV (OR, 2.8 [95% CI, 2.0–4.1]; AFE, 65%) in older adults presenting with ARI, compared with those without respiratory symptoms (ie, asymptomatic individuals) or healthy older adults. However, there was no significant difference in the detection of BoV in cases and controls. This review supports RSV, Flu, PIV, HMPV, AdV, RV, and CoV as important causes of ARI in older adults and provides quantitative estimates of the absolute proportion of virus-associated ARI cases to which a viral cause can be attributed. Disease burden estimates should take into account the appropriate AFE estimates (for older adults) that we report.
has issue date	2019-03-08(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy662
bibo:pmid	30849176
has license	cc-by
sha1sum (hex)	0e7881e97024fe722e03b821d76391d8361a8008
schema:url	https://doi.org/10.1093/infdis/jiy662
resource representing a document's title	The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis
has PubMed Central identifier	PMC7107439
has PubMed identifier	30849176
schema:publication	J Infect Dis
resource representing a document's body	covid:0e7881e97024fe722e03b821d76391d8361a8008#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0e7881e97024fe722e03b821d76391d8361a8008
is schema:about of	named entity 'virus' named entity 'aged' named entity '95% CI' named entity 'potential' named entity 'Respiratory' named entity 'Infections' named entity 'STUDIES' named entity 'ARI' named entity '3.9' named entity 'INFLUENZA VIRUS' named entity 'CONFIDENCE INTERVAL' named entity 'PARAINFLUENZA VIRUS' named entity 'BURDEN' named entity 'ELDERLY INDIVIDUALS' named entity 'META-ANALYSIS' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity '4.4' named entity 'AGED' covid:arg/0e7881e97024fe722e03b821d76391d8361a8008 named entity 'POSSIBLE' named entity 'ADENOVIRUS' named entity 'DISEASE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'PIV' named entity 'CASE-CONTROL STUDIES' named entity '4.1' named entity 'CORONAVIRUS' named entity 'INVESTIGATING' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PROFILE' named entity '100%' named entity 'APPROXIMATELY' named entity '9-18' named entity 'VIRAL' named entity 'ROLE' named entity 'SYSTEMATIC REVIEW' named entity '80%' named entity 'COMMON' named entity 'BOCAVIRUS' named entity 'ETIOLOGY' named entity 'ADULTS' named entity 'EXPOSED' named entity 'LITERATURE REVIEW' named entity '8.5' named entity 'INCLUDED' named entity 'COMPUTED' named entity 'PUBLISHED' named entity 'ADV' named entity 'ROLE' named entity 'VIRUS' named entity 'ACUTE' named entity 'ATTRIBUTABLE' named entity 'ARI' named entity 'FRACTION' named entity 'RSV' named entity 'SPECIFIC' named entity '13.6' named entity 'ATTRIBUTION' named entity 'RESPIRATORY VIRUSES' named entity '3.7' named entity 'AFE' named entity 'VIRUSES' named entity 'POTENTIAL' named entity 'RHINOVIRUS' named entity '2019' named entity 'DATABASES' named entity 'YEARS' named entity 'NOT AVAILABLE' named entity 'TO IDENTIFY' named entity '18.5' named entity 'STRONG' named entity 'COMMON'

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