About: Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study

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About: Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study
Creator	Akira Ishii, · Ando, Masahiko Kimitoshi, · Kubo, Yoko Mori, Atsushi Tamura, Takahiro
Source	PMC
abstract	PURPOSE: Volatile anesthetics (VAs) protect myocardial cells in cardiovascular surgery. A recent clinical trial of cardiopulmonary bypass (CPB) surgery reported no significant difference in mortality rates between the use of VAs and total intravenous anesthetics at 1 year postoperatively. However, oxygenator function may affect the VA pharmacokinetics. Thus, we measured the VA blood concentrations during CPB in patients managed with four different microporous polypropylene hollow fiber membrane oxygenators. METHODS: Twenty-four patients scheduled for elective CPB were randomly allocated to one of the two VA groups (desflurane and sevoflurane groups) and, then, randomly divided into one of four oxygenator groups: Terumo, LivaNova, Medtronic, and Senko (n = 3). Additionally, in each VA group, three patients were randomly selected and redundantly allocated to the human lung group (for control blood VA concentration without oxygenator). Blood samples collected 20 min after starting 6.0 vol% desflurane or 1.7 vol% sevoflurane were analyzed using gas chromatography. Oxygenator-related complications and structural changes in the membrane surface of each oxygenator after surgery were evaluated. RESULTS: The mean (standard deviation) concentrations of desflurane and sevoflurane in the human lung were 182.4 (23.2) and 54.0 (9.6) μg/ml, respectively; not significantly different from those in the four oxygenator groups. No oxygenator-related complications occurred. Structural changes in membrane fibers did not occur after clinical use, except for difficulty in image acquisition with Senko products. CONCLUSION: Our results demonstrated that the blood concentrations of desflurane and sevoflurane passing through oxygenators used during CPB were similar to those in the human lung control. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00540-020-02844-1) contains supplementary material, which is available to authorized users.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1007/s00540-020-02844-1
has license	no-cc
sha1sum (hex)	0eb0709167c38890dad1f603a5d0be1799842143
schema:url	https://doi.org/10.1007/s00540-020-02844-1
resource representing a document's title	Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study
has PubMed Central identifier	PMC7449527
schema:publication	J Anesth
resource representing a document's body	covid:0eb0709167c38890dad1f603a5d0be1799842143#body_text
is schema:about of	named entity 'polypropylene' named entity 'control' named entity 'desflurane' named entity 'patients' named entity 'starting' named entity 'oxygenator' named entity 'oxygenator' named entity 'elective' named entity 'pharmacokinetics' named entity 'concentrations' named entity 'randomized' named entity 'FIBERS' named entity 'OXYGENATOR' named entity 'SIGNIFICANT' named entity 'PHARMACOKINETICS' named entity 'CONCENTRATION' named entity 'SCHEDULED' named entity 'VOLATILE' named entity 'DIVIDED' named entity 'GROUPS' named entity 'HUMAN LUNG' named entity 'YEAR' named entity 'IMAGE ACQUISITION' named entity 'EVALUATED' named entity 'MORTALITY RATES' named entity 'surgery' named entity 'desflurane' named entity 'human lung' named entity 'patients' named entity 'randomly' named entity 'blood' named entity 'products' named entity 'Volatile' named entity 'concentrations' named entity 'intravenous' named entity 'gas chromatography' named entity 'divided' named entity 'sevoflurane' named entity 'Thus' named entity 'managed' named entity 'membrane' named entity 'cardiopulmonary bypass' named entity 'desflurane' named entity 'sevoflurane' named entity 'sevoflurane' named entity 'standard deviation' named entity 'mortality rates' named entity 'sevoflurane' named entity 'cardiopulmonary bypass' named entity 'oxygenator' named entity 'image acquisition' named entity 'desflurane' named entity 'polypropylene' named entity 'Medtronic' named entity 'oxygenator' named entity 'intravenous' named entity 'membrane surface' named entity 'LivaNova' named entity 'aortic cross-clamping' named entity 'Japan' named entity 'Kyoto' named entity 'human lung' named entity 'blood samples' named entity 'Mann-Whitney U test' named entity 'desflurane' named entity 'dopamine' named entity 'general anesthesia' named entity 'oxygenator' named entity 'St. Louis' named entity 'general anesthesia' named entity 'statistical significance' named entity 'hematocrit' named entity 'blood pressure' named entity 'oxygenator' named entity 'randomly selected' named entity 'sevoflurane' named entity 'cannula' named entity 'sevoflurane'

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