About: Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury
Creator	Mooney, Catherine Bjorkman, Tracey Boylan, Geraldine Brennan, Gary Burke, Christopher Casey, Sophie Cowin, Gary Goasdoue, Kate Hallberg, Boubou Henshall, David Miller, Stephanie Murray, Deirdre Sullivan, Aideen O'keeffe, Gerard O'mahony, Adam
source	PMC
abstract	Hypoxic ischemic encephalopathy (HIE) is the most frequent cause of acquired infant brain injury. Early, clinically relevant biomarkers are required to allow timely application of therapeutic interventions. We previously reported early alterations in several microRNAs (miRNA) in umbilical cord blood at birth in infants with HIE. However, the exact timing of these alterations is unknown. Here, we report serial changes in six circulating, cross-species/bridging biomarkers in a clinically relevant porcine model of neonatal HIE with functional analysis. Six miRNAs—miR-374a, miR-181b, miR-181a, miR-151a, miR-148a and miR-128—were significantly and rapidly upregulated 1-h post-HI. Changes in miR-374a, miR-181b and miR-181a appeared specific to moderate-severe HI. Histopathological injury and five miRNAs displayed positive correlations and were predictive of MRS Lac/Cr ratios. Bioinformatic analysis identified that components of the bone morphogenic protein (BMP) family may be targets of miR-181a. Inhibition of miR-181a increased neurite length in both SH-SY5Y cells at 1 DIV (days in vitro) and in primary cultures of rat neuronal midbrain at 3 DIV. In agreement, inhibition of miR-181a increased expression of BMPR2 in differentiating SH-SY5Y cells. These miRNAs may therefore act as early biomarkers of HIE, thereby allowing for rapid diagnosis and timely therapeutic intervention and may regulate expression of signalling pathways vital to neuronal survival. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12035-020-02018-w) contains supplementary material, which is available to authorized users.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1007/s12035-020-02018-w
has license	no-cc
sha1sum (hex)	10244a4904abf5635bb0acdafe05d10b3c674be8
schema:url	https://doi.org/10.1007/s12035-020-02018-w
resource representing a document's title	Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury
has PubMed Central identifier	PMC7383124
schema:publication	Mol Neurobiol
resource representing a document's body	covid:10244a4904abf5635bb0acdafe05d10b3c674be8#body_text
is schema:about of	named entity 'Histopathological' named entity 'expression' named entity 'timely' named entity 'early' named entity 'neuronal' named entity 'diagnosis' named entity 'Hypoxic' named entity 'RELEVANT' named entity 'ALLOWING' named entity 'ANALYSIS' named entity 'HYPOXIC ISCHEMIC ENCEPHALOPATHY' named entity 'MRS' named entity 'UMBILICAL CORD BLOOD' named entity 'HERE' named entity 'FUNCTIONAL ANALYSIS' named entity 'RATIOS' named entity 'DIV' named entity 'BMPR2' named entity 'IDENTIFIED' named entity 'PROTEIN ' named entity 'COMPONENTS' named entity 'MAY BE' named entity 'AGREEMENT' named entity 'circulating' named entity 'biomarkers' named entity 'differentiating' named entity 'Six' named entity 'survival' named entity 'miRNAs' named entity 'alterations' named entity 'length' named entity 'rapidly' named entity 'bone morphogenic protein' named entity 'rat' named entity 'neonatal' named entity 'Hypoxic ischemic encephalopathy' named entity 'miRNAs' named entity 'miRNAs' named entity 'HIE' named entity 'upregulated' named entity 'signalling pathways' named entity 'midbrain' named entity 'porcine' named entity 'miR' named entity 'cross-species' named entity 'Histopathological' named entity 'umbilical cord blood' named entity 'miR' named entity 'miRNA' named entity 'HIE' named entity 'application' named entity 'histopathological examination' named entity 'PCR' named entity 'transcription' named entity 'HIE' named entity 'spectrophotometer' named entity 'Sigma-Aldrich' named entity 'cell receptor' named entity 'fat pad' named entity 'HIE' named entity 'BSA' named entity 'University of Queensland' named entity 'miR' named entity 'cross-species' named entity 'miRNAs' named entity 'physiological responses' named entity 'miRNAs' named entity 'miR' named entity 'Australia'

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