About: Croup Is Associated with the Novel Coronavirus NL63

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Croup Is Associated with the Novel Coronavirus NL63
Creator	Berkhout, Ben Forster, Johannes Ihorst, Gabriele Sure, Klaus Pyrc, Krzysztof Jebbink, Maarten Stang, Alexander Petersen, Gudula Van Der Hoek, Lia Berla, Klaus
source	Medline; PMC
abstract	BACKGROUND: The clinical relevance of infections with the novel human coronavirus NL63 (HCoV-NL63) has not been investigated systematically. We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI). METHODS AND FINDINGS: Nine hundred forty-nine samples of nasopharyngeal secretions from children under 3 y of age with LRTIs were analysed by a quantitative HCoV-NL63-specific real-time PCR. The samples had been collected from hospitalised patients and outpatients from December 1999 to October 2001 in four different regions in Germany as part of the prospective population-based PRI.DE study and analysed for RNA from respiratory viruses. Forty-nine samples (5.2%), mainly derived from the winter season, were positive for HCoV-NL63 RNA. The viral RNA was more prevalent in samples from outpatients (7.9%) than from hospitalised patients (3.2%, p = 0.003), and co-infection with either respiratory syncytial virus or parainfluenza virus 3 was observed frequently. Samples in which only HCoV-NL63 RNA could be detected had a significantly higher viral load than samples containing additional respiratory viruses (median 2.1 × 10(6) versus 2.7 × 10(2) copies/ml, p = 0.0006). A strong association with croup was apparent: 43% of the HCoV-NL63-positive patients with high HCoV-NL63 load and absence of co-infection suffered from croup, compared to 6% in the HCoV-NL63-negative group, p < 0.0001. A significantly higher fraction (17.4%) of samples from croup patients than from non-croup patients (4.2%) contained HCoV-NL63 RNA. CONCLUSION: HCoV-NL63 infections occur frequently in young children with LRTI and show a strong association with croup, suggesting a causal relationship.
has issue date	2005-08-23(xsd:dateTime)
bibo:doi	10.1371/journal.pmed.0020240
bibo:pmid	16104827
has license	cc-by
sha1sum (hex)	10e691d6bf9cfc219bb72a2761d37ae5f1677f77
schema:url	https://doi.org/10.1371/journal.pmed.0020240
resource representing a document's title	Croup Is Associated with the Novel Coronavirus NL63
has PubMed Central identifier	PMC1188248
has PubMed identifier	16104827
schema:publication	PLoS Med
resource representing a document's body	covid:10e691d6bf9cfc219bb72a2761d37ae5f1677f77#body_text
is schema:about of	named entity 'NOVEL CORONAVIRUS' named entity 'CORONAVIRUS NL63' named entity 'CROUP' named entity 'ASSOCIATED WITH' named entity 'Croup' named entity 'RSV' named entity 'viral load' named entity 'assay' named entity 'early winter' named entity 'RSV' named entity 'viruses' named entity 'croup' named entity 'PRI' named entity 'Nucleic acid' named entity 'lower respiratory tract infections' named entity 'RSV' named entity 'Invitrogen' named entity 'fluorescence' named entity 'bronchiolitis' named entity 'apnoea' named entity 'detection limit' named entity '10:4' named entity 'co-infected' named entity 'LRTI' named entity 'virus' named entity 'cough' named entity 'respiratory disease' named entity 'HCoV-NL63' named entity 'RNA' named entity '2.1' named entity 'viruses' named entity 'viral load' named entity 'infection' named entity 'PCR' named entity 'human coronavirus' named entity 'HCoV-NL63' named entity 'pathogen' named entity 'RNA' named entity 'croup' named entity 'HCoV-NL63' named entity 'real-time PCR' named entity 'viruses' named entity 'virus' named entity 'RNA' named entity 'odds ratios' named entity 'HCoV-NL63' named entity 'innate immune responses' named entity 'croup' named entity 'United States' named entity 'HCoV-NL63' named entity 'RSV' named entity 'Quantitative PCR' named entity 'Qiagen' named entity 'Croup' named entity 'outpatient' named entity 'RSV' named entity 'HCoV-NL63' named entity 'HCoV-NL63' named entity 'respiratory diseases' named entity 'RSV' named entity 'Japan' named entity 'viruses' named entity 'Germany' named entity 'Wisconsin' named entity 'RSV infection' named entity 'RSV' named entity 'RNA' named entity 'PRI' named entity 'PCR' named entity 'HCoV-NL63' named entity 'Signs and symptoms' named entity 'HCoV-NL63'

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