About: Nasopharyngeal Swabs Are More Sensitive Than Oropharyngeal Swabs for COVID-19 Diagnosis and Monitoring the SARS-CoV-2 Load

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About: Nasopharyngeal Swabs Are More Sensitive Than Oropharyngeal Swabs for COVID-19 Diagnosis and Monitoring the SARS-CoV-2 Load Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nasopharyngeal Swabs Are More Sensitive Than Oropharyngeal Swabs for COVID-19 Diagnosis and Monitoring the SARS-CoV-2 Load
Creator	Zhou, Min Xu, Dong Wang, Huan Li, Wen Wang, Feng Liu, Qian Yin, Ping Li, Yu Hu, Jing Kozlakidis, Zisis Xiao, Yao Li, Kai-Yan Lu, Yan-Jun Xu, Shu-Yun Yang, Jun-Yi Yu, Mu-Qing Zhang, Huanping
source	Medline; PMC
abstract	Objective: Detection of SARS-CoV-2 by oropharyngeal swabs (OPS) and nasopharyngeal swabs (NPS) is an essential method for coronavirus disease 2019 (COVID-19) management. It is not clear how detection rate, sensitivity, and the risk of exposure for medical providers differ in two sampling methods. Methods: In this prospective study, 120 paired NPS and OPS specimens were collected from 120 inpatients with confirmed COVID-19. SARS-CoV-2 nucleic acid in swabs were detected by real-time RT-PCR. The SARS-CoV-2 detection rate, sensitivity, and viral load were analyzed with regards NPS and OPS. Sampling discomfort reported by patients was evaluated. Results: The SARS-CoV-2 detection rate was significantly higher for NPS [46.7% (56/120)] than OPS [10.0% (12/120)] (P < 0.001). The sensitivity of NPS was also significantly higher than that of OPS (P < 0.001). At the time of sampling, the time of detectable SARS-CoV-2 had a longer median duration (25.0 vs. 20.5 days, respectively) and a longer maximum duration (41 vs. 39 days, respectively) in NPS than OPS. The mean cycle threshold (Ct) value of NPS (37.8, 95% CI: 37.0–38.6) was significantly lower than that of OPS (39.4, 95% CI: 38.9–39.8) by 1.6 (95% CI 1.0–2.2, P < 0.001), indicating that the SARS-CoV-2 load was significantly higher in NPS specimens than OPS. Patient discomfort was low in both sampling methods. During NPS sampling, patients were significantly less likely to have nausea and vomit. Conclusions: NPS had significantly higher SARS-CoV-2 detection rate, sensitivity, and viral load than OPS. NPS could reduce droplets production during swabs. NPS should be recommended for diagnosing COVID-19 and monitoring SARS-CoV-2 load. Chinese Clinical Trial Registry, number: ChiCTR2000029883.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.3389/fmed.2020.00334
bibo:pmid	32626720
has license	cc-by
sha1sum (hex)	113b304ee47b4fa103acf8abfc7d3f5a5efa0df7
schema:url	https://doi.org/10.3389/fmed.2020.00334
resource representing a document's title	Nasopharyngeal Swabs Are More Sensitive Than Oropharyngeal Swabs for COVID-19 Diagnosis and Monitoring the SARS-CoV-2 Load
has PubMed Central identifier	PMC7314917
has PubMed identifier	32626720
schema:publication	Front Med (Lausanne)
resource representing a document's body	covid:113b304ee47b4fa103acf8abfc7d3f5a5efa0df7#body_text
is schema:about of	named entity 'sensitivity' named entity 'management' named entity 'swabs' named entity 'Detection' named entity 'Load' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'COVID-19' named entity 'Oropharyngeal' named entity '37 days' named entity 'visual analog scale' named entity 'comorbidities' named entity 'prospective study' named entity 'COVID-19' named entity 'OPS' named entity 'influenza' named entity 'vomit' named entity 'OPS' named entity 'nausea' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'OPS' named entity 'electronic medical records' named entity 'design of the study' named entity 'symptom' named entity 'SARS-CoV-2' named entity 'quarantine' named entity 'SARS-CoV-2' named entity 'sample size' named entity 'SARS-CoV-2' named entity 'prospective study' named entity 'OPS' named entity 'RT-PCR' named entity '3.5' named entity 'PCR' named entity 'OPS' named entity '21 days' named entity 'cough' named entity 'face mask' named entity 'vomit' named entity 'OPS' named entity 'OPS' named entity 'OPS' named entity 'OPS' named entity 'COVID' named entity 'OPS' named entity 'clinical characteristics' named entity 'OPS' named entity 'nostril' named entity 'RT-PCR' named entity 'OPS' named entity 'Beijing' named entity 'McNemar's test' named entity 'OPS' named entity 'reverse transcription' named entity 'influenza' named entity '1.6' named entity 'vomit' named entity 'sampling methods' named entity 'OPS' named entity 'Wuhan' named entity 'infection' named entity 'OPS' named entity 'lachrymation' named entity 'sneezing'

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