About: Coronavirus Transcription Mediated by Sequences Flanking the Transcription Consensus Sequence

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus Transcription Mediated by Sequences Flanking the Transcription Consensus Sequence
Creator	Makino, Shinji Hwang, Sun-Min Jeong, Kim, Young-Nam Repass, John Yong, Seok
topic	covid:121d6115779d455aa909ca67331aa248b6ebf7f9#this
Source	Elsevier; Medline; PMC
abstract	Abstract In our studies of murine coronavirus transcription, we continue to use defective interfering (DI) RNAs of mouse hepatitis virus (MHV) in which we insert a transcription consensus sequence in order to mimic subgenomic RNA synthesis from the nondefective genome. Using our subgenomic DI system, we have studied the effects of sequences flanking the MHV transcription consensus sequence on subgenomic RNA transcription. We obtained the following results. (i) Insertion of a 12-nucleotide-long sequence including the UCUAAAC transcription consensus sequence at different locations of the DI RNA resulted in different efficiencies of subgenomic DI RNA synthesis. (ii) Differences in the amount of subgenomic DI RNA were defined by the sequences that flanked the 12-nucleotide-long sequence and were not affected by the location of the 12-nucleotide-long sequence on the DI RNA. (iii) Naturally occurring flanking sequences of intergenic sequences at gene 6–7, but not at genes 1–2 and 2–3, contained a transcription suppressive element(s). (iv) Each of three naturally occurring flanking sequences of an MHV genomic cryptic transcription consensus sequence from MHV gene 1 also contained a transcription suppressive element(s). These data showed that sequences flanking the transcription consensus sequence affected MHV transcription.
has issue date	1996-03-01(xsd:dateTime)
bibo:doi	10.1006/viro.1996.0118
bibo:pmid	8599216
has license	els-covid
sha1sum (hex)	121d6115779d455aa909ca67331aa248b6ebf7f9
schema:url	https://doi.org/10.1006/viro.1996.0118
resource representing a document's title	Coronavirus Transcription Mediated by Sequences Flanking the Transcription Consensus Sequence
has PubMed Central identifier	PMC7131137
has PubMed identifier	8599216
schema:publication	Virology
resource representing a document's body	covid:121d6115779d455aa909ca67331aa248b6ebf7f9#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/121d6115779d455aa909ca67331aa248b6ebf7f9 proxy:http/ns.inria.fr/covid19/121d6115779d455aa909ca67331aa248b6ebf7f9
is schema:about of	named entity 'transcription' named entity 'genes' named entity 'sequence' named entity 'gene' named entity 'addressed' named entity 'system' named entity 'data' named entity 'MHV' named entity 'element' named entity 'Each' named entity 'sequences' named entity 'cis' named entity 'consensus sequence' named entity 'subgenomic' named entity 'RNA' named entity 'RNA' named entity 'intergenic regions' named entity 'intergenic' named entity 'RNAs' named entity 'subgenomic' named entity 'MHV' named entity 'RNA' named entity 'TGEV' named entity 'RNA transcription' named entity 'MHV' named entity 'protein' named entity 'subgenomic RNA' named entity 'regulatory control' named entity 'evolution' named entity 'MHV' named entity 'transfected' named entity 'transfection' named entity 'subgenomic' named entity 'MHV' named entity 'mRNAs' named entity 'virus' named entity 'MHV' named entity 'intergenic' named entity 'subgenomic' named entity 'transfected' named entity 'RNA' named entity 'transfected' named entity 'mRNA' named entity 'protein' named entity 'transfected' named entity 'cloned' named entity 'RT-PCR' named entity 'XbaI' named entity 'Hiscox' named entity 'RNA' named entity 'RNA' named entity 'intergenic' named entity 'leader sequence' named entity 'MHV' named entity 'Northern blot analysis' named entity 'RNA' named entity 'upstream and downstream' named entity 'MHV' named entity 'subgenomic' named entity 'transcriptionally active' named entity 'RNA' named entity 'primers' named entity 'intergenic' named entity 'genome' named entity 'RNA' named entity 'intracellular' named entity 'RNA' named entity 'infection' named entity 'subgenomic' named entity 'MHV' named entity 'coronavirus' named entity 'RNA transcription' named entity 'MHV'

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