About: Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation
Creator	Arias, Pablo Cruces, Pablo Díaz, Franco González-Dambrauskas, Sebastián Martínez, Javier Quilodrán, Julio Rivero, Natalia Valenzuela, Jorge
Source	PMC
abstract	BACKGROUND: Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Our aim was to discriminate the components of the working pressure of the respiratory system in infants on MV with severe bronchiolitis admitted to two PICU’s. METHODS: Infants younger than 1 year old with acute respiratory failure caused by severe bronchiolitis underwent neuromuscular blockade, tracheal intubation and volume controlled MV. Shortly after intubation studies of pulmonary mechanics were performed using inspiratory and expiratory breath hold. The maximum inspiratory and expiratory flow (QI and QE) as well as peak inspiratory (PIP), plateau (PPL) and total expiratory pressures (tPEEP) were measured. Inspiratory and expiratory resistances (RawI and RawE) and Time Constants (K(TI) and K(TE)) were calculated. RESULTS: We included 16 patients, of median age 2.5 (1–5.8) months. Bronchiolitis due to respiratory syncytial virus was the main etiology (93.8%) and 31.3% had comorbidities. Measured respiratory pressures were PIP 29 (26–31), PPL 24 (20–26), tPEEP 9 [8–11] cmH2O. Elastic component of the working pressure was significantly higher than resistive and both higher than threshold (tPEEP – PEEP) (P < 0.01). QI was significantly lower than QE [5 (4.27–6.75) v/s 16.5 (12–23.8) L/min. RawI and RawE were 38.8 (32–53) and 40.5 (22–55) cmH2O/L/s; K(TI) and K(TE) [0.18 (0.12–0.30) v/s 0.18 (0.13–0.22) s], and K(TI):K(TE) ratio was 1:1.04 (1:0.59–1.42). CONCLUSIONS: Analysis of respiratory mechanics of infants with severe bronchiolitis receiving MV shows that the elastic component of the working pressure of the respiratory system is the most important. The elastic and resistive components in conjunction with flow profile are characteristic of restrictive diseases. A better understanding of lung mechanics in this group of patients may lead to change the traditional ventilatory approach to severe bronchiolitis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12890-017-0475-6) contains supplementary material, which is available to authorized users.
has issue date	2017-10-06(xsd:dateTime)
bibo:doi	10.1186/s12890-017-0475-6
bibo:pmid	28985727
has license	cc-by
sha1sum (hex)	12a2bcf83180c3f45167bea9a42988d81d9d7092
schema:url	https://doi.org/10.1186/s12890-017-0475-6
resource representing a document's title	Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation
has PubMed Central identifier	PMC6389183
has PubMed identifier	28985727
schema:publication	BMC Pulm Med
resource representing a document's body	covid:12a2bcf83180c3f45167bea9a42988d81d9d7092#body_text
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