About: Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome()

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About: Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome()
Creator	Duan, Zhao-Hui Zeng, Yi-Xin Li, Yan Huang, Wenlin Liu, Ran-Yi Huang, Jian Wei, Jing Huang, Bi-Jun Huang, Jia-Ling Tan, Wei-Ping Wu, Li-Zhi Li, Jian-Guo Luo, Xiao-Hong Min, Jun Shao, Jing
Source	Elsevier; Medline; PMC
abstract	The immune spectrum of severe acute respiratory syndrome (SARS) is poorly understood. To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. Results showed that interleukin (IL)-10 and transforming growth factor β (TGF-β) were continuously up-regulated during the entirety of SARS. Regulated on activation normally T cell-expressed and secreted (RANTES) levels were decreased, while monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. Immunoglobulins and complement were elevated during the first month of SARS. Both serum-positive rates and titers of specific IgM and IgG antibodies responding to SARS-CoV peaked at days 41–60 from the onset of SARS. CD4+ and CD8+ T lymphocytes decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were decreased by 36.78% in the convalescent patients. Conclusion: SARS-CoV seemed to elicit effective humoral immunity but inhibited cellular immunity, especially CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and TGF-β may play an important role in the disease.
has issue date	2005-02-24(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2004.11.017
bibo:pmid	15784184
has license	no-cc
sha1sum (hex)	12cbe2a227e6ecb1875a1b47df558c00d610e7b4
schema:url	https://doi.org/10.1016/j.micinf.2004.11.017
resource representing a document's title	Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome()
has PubMed Central identifier	PMC7110803
has PubMed identifier	15784184
schema:publication	Microbes Infect
resource representing a document's body	covid:12cbe2a227e6ecb1875a1b47df558c00d610e7b4#body_text
is schema:about of	named entity 'continuously' named entity 'T lymphocytes' named entity 'severe acute respiratory syndrome (SARS)' named entity 'convalescent' named entity 'protein' named entity 'spectrum' named entity 'up-regulated' covid:arg/12cbe2a227e6ecb1875a1b47df558c00d610e7b4 named entity 'growth factor' named entity 'immunoglobulins' named entity 'activation' named entity 'cellular immunity' named entity 'CD8+' named entity 'correlation' named entity 'CD3+CD8+' named entity 'SARS' named entity 'lymphocytes' named entity 'interleukins' named entity 'anti-viral therapy' named entity 'CD8+' named entity 'infection' named entity 'apoptosis' named entity 'IL-4' named entity 'virus' named entity 'statistically significant' named entity 'Student's t-test' named entity 'memory T cells' named entity 'Austria' named entity 'infection' named entity 'SARS-CoV' named entity 'IgG' named entity 'chemokine' named entity 'aspartate aminotransferase' named entity 'correlation coefficient' named entity 'murine' named entity 'coronavirus' named entity 'optical density' named entity 'lymphocytes' named entity 'IL-10' named entity 'BD Biosciences' named entity 'peripheral' named entity 'SARS-CoV' named entity '37°C' named entity 'coronaviruses' named entity 'chemokine' named entity 'steroid' named entity 'correlation coefficient' named entity 'infection' named entity 'humoral responses' named entity 'neutralizing antibodies' named entity 'immune response' named entity 'Serum' named entity 'enzyme immunoassay' named entity 'leukopenia' named entity 'humoral immune' named entity 'RANTES' named entity 'lymphocytes' named entity 'seropositive' named entity 'CD8+ T lymphocytes' named entity 'SARS-CoV' named entity 'chemotactic' named entity 'steroids' named entity 'SARS' named entity 'microplate' named entity 'one-way ANOVA' named entity 'lymphocytes' named entity 'murine'

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