About: The HCV Replicase Complex and Viral RNA Synthesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The HCV Replicase Complex and Viral RNA Synthesis
Creator	Romero-Brey, Inés Lohmann, Volker Lohmann, • Romero-Brey, I
source	PMC
abstract	Replication of hepatitis C virus (HCV) is tightly linked to membrane alterations designated the membranous web, harboring the viral replicase complex. In this chapter we describe the morphology and 3D architecture of the HCV-induced replication organelles, mainly consisting of double membrane vesicles, which are generated by a concerted action of the nonstructural proteins NS3 to NS5B. Recent studies have furthermore identified a number of host cell proteins and lipids contributing to the biogenesis of the membranous web, which are discussed in this chapter. Viral RNA synthesis is tightly associated with these membrane alterations and mainly driven by the viral RNA dependent RNA polymerase NS5B. We summarize our current knowledge of the structure and function of NS5B, the role of cis-acting replication elements at the termini of the genome in regulating RNA synthesis and the contribution of additional viral and host factors to viral RNA synthesis, which is still ill defined.
has issue date	2016-04-08(xsd:dateTime)
bibo:doi	10.1007/978-4-431-56098-2_8
has license	no-cc
sha1sum (hex)	13285ec069b250833388b90d0d296ab091d8319b
schema:url	https://doi.org/10.1007/978-4-431-56098-2_8
resource representing a document's title	The HCV Replicase Complex and Viral RNA Synthesis
has PubMed Central identifier	PMC7122888
schema:publication	Hepatitis C Virus I
resource representing a document's body	covid:13285ec069b250833388b90d0d296ab091d8319b#body_text
is schema:about of	named entity 'membranous' named entity 'NS5B' named entity 'action' named entity 'number' named entity 'resistant' named entity 'vesicle' named entity 'DRM' named entity 'Dengue virus' named entity 'structural' named entity 'RNA dependent RNA polymerase' named entity 'DMV' named entity 'membrane' named entity 'MMV' named entity 'Complex' named entity 'ACTING' named entity 'NONSTRUCTURAL PROTEINS' named entity 'VIRAL RNA' named entity 'ROLE' named entity 'IDENTIFIED' named entity 'NS5B' named entity 'proteins' named entity 'Viral' named entity 'web' named entity 'defined' named entity 'organelles' named entity 'membranous' named entity 'genome' named entity 'RNA' named entity 'genome' named entity 'nonstructural proteins' named entity 'morphology' named entity 'cis-acting' named entity 'NS5B' named entity 'RNA synthesis' named entity 'replication elements' named entity 'biogenesis' named entity 'Viral' named entity 'Oxysterol-binding protein' named entity 'vesicle' named entity 'PI4P' named entity 'Phosphatidylinositol 4-phosphate' named entity 'Endoplasmic reticulum' named entity 'RNA' named entity 'DENV' named entity 'OSBP' named entity 'double' named entity 'cis' named entity 'cholesterol' named entity 'RNA' named entity 'OCLN' named entity 'polymerase' named entity 'biogenesis' named entity 'HCV' named entity 'subspecies' named entity 'PI4P' named entity 'lipid bilayers' named entity 'DMVs' named entity 'polyprotein' named entity 'gamma group' named entity 'nucleus' named entity 'NS5A inhibitors' named entity 'complementation' named entity 'autophagy' named entity 'scavenger receptor' named entity 'Legalon' named entity 'VAP-A' named entity 'invagination' named entity 'secondary structures' named entity 'positive and negative' named entity 'RNA synthesis' named entity 'NS4B' named entity 'DMVs' named entity 'Silibinin' named entity 'DMVs' named entity 'proteins interact' named entity 'GBF1' named entity 'membrane-bound' named entity '3D reconstruction' named entity 'viral proteins' named entity 'NS5A'

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