About: HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders

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About: HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders
Creator	Wang, · Balagué, Olga López-Guillermo, Armando Marginet, Marta Sanchez, Sandra Antonio Martínez, · Campo, · Luis Veloza, · Mónica López, ·
source	PMC
abstract	Human herpesvirus type 8 (HHV8) is a gamma herpesvirus known for its role in lymphoid neoplasms, especially in immunosuppressed patients. We describe the case of a 64-year-old male, without known immunodeficiency, with 1-year-long clinical history of mediastinal and abdominal lymphadenopathies and recurrent pulmonary infections. Histopathological evaluation of a mediastinal lymph node revealed the presence of scattered atypical large cells with Hodgkin and Reed–Sternberg morphology in a background of lymphocytes and extensive areas of fibrosis. The large cells were positive for HHV8 and Epstein–Barr virus (EBV), with a clonal pattern of IGH gene rearrangement. A descriptive diagnosis of “HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma” was rendered. Interestingly, the retrospective evaluation of a previous biopsy, diagnosed as reactive lymphadenitis, revealed the presence of HHV8- and EBV-positive cells, with a polyclonal pattern and a small peak corresponding to that of the most recent biopsy. This case presents diagnostic challenges due to the presence of particular features not clearly related to current HHV8-associated entities, and also suggests the possibility for disease progression in the spectrum of HHV8- and EBV-associated lymphoproliferative disorders.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.1007/s12185-020-02897-8
has license	no-cc
sha1sum (hex)	148b99c6553c0622a88ae4a37c5396ff5ddd968b
schema:url	https://doi.org/10.1007/s12185-020-02897-8
resource representing a document's title	HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders
has PubMed Central identifier	PMC7287409
schema:publication	Int J Hematol
resource representing a document's body	covid:148b99c6553c0622a88ae4a37c5396ff5ddd968b#body_text
is schema:about of	named entity 'cells' named entity 'lymphoid' named entity 'diagnosis' named entity 'herpesvirus' named entity 'cells' named entity 'EBV' named entity 'Human' named entity 'virus' named entity 'peak' named entity 'OLD' named entity 'FEATURES' named entity 'IMMUNOSUPPRESSED PATIENTS' named entity 'REVEALED' named entity 'DIAGNOSIS' named entity 'HERPESVIRUS' named entity 'TYPE' named entity 'CURRENT' named entity 'LIKE' named entity 'LYMPHADENOPATHIES' named entity 'AREAS OF FIBROSIS' named entity 'RECURRENT PULMONARY INFECTIONS' named entity 'MORPHOLOGY' named entity 'CLINICAL HISTORY' named entity 'HUMAN HERPESVIRUS' named entity 'DESCRIBE' named entity 'EXTENSIVE' named entity 'POSITIVE FOR' named entity 'polyclonal' named entity 'type' named entity 'background' named entity 'large B-cell lymphoma' named entity 'extensive' named entity 'immunosuppressed' named entity 'The' named entity 'clonal' named entity 'lymphoproliferative disorders' named entity 'retrospective' named entity 'EBV' named entity 'HHV8' named entity 'EBV' named entity 'clinical history' named entity 'HHV8' named entity 'HHV8' named entity 'immunodeficiency' named entity 'morphology' named entity 'Histopathological' named entity 'gene rearrangement' named entity 'Epstein-Barr' named entity 'Hodgkin lymphoma' named entity 'EBV' named entity 'HHV8' named entity 'morphology' named entity 'abdominal' named entity 'EMA' named entity 'Hodgkin' named entity 'HHV8' named entity 'differential diagnosis' named entity 'HHV8' named entity 'mediastinal' named entity 'HHV8' named entity 'PET-CT' named entity 'EBV' named entity 'multicentric Castleman disease' named entity 'MUM1' named entity 'T-cell' named entity 'up-regulation' named entity 'CT imaging' named entity 'biopsy' named entity 'lymphadenopathies' named entity 'lymphoid tissue' named entity 'glomerular filtration rate' named entity 'IgM' named entity 'HHV8' named entity 'IgD' named entity 'CD5'

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