About: Minimal system for assembly of SARS-CoV-2 virus like particles

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Minimal system for assembly of SARS-CoV-2 virus like particles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Minimal system for assembly of SARS-CoV-2 virus like particles
Creator	Belnap, David Eldridge, Crystal Peterson, Abby Preece, Benjamin Saffarian, Saveez Sharma, Abhimanyu Swann, Heather Vershinin, Michael
source	BioRxiv
abstract	SARS-CoV-2 virus is the causative agent of COVID-19. Here we demonstrate that non-infectious SARS-CoV-2 virus like particles (VLPs) can be assembled by co-expressing the viral proteins S, M and E in mammalian cells. The assembled SARS-CoV-2 VLPs possess S protein spikes on particle exterior, making them ideal for vaccine development. The particles range in shape from spherical to elongated with a characteristic size of 129 ± 32 nm. We further show that SARS-CoV-2 VLPs dried in ambient conditions can retain their structural integrity upon repeated scans with Atomic Force Microscopy up to a peak force of 1 nN.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.06.01.128058
has license	biorxiv
sha1sum (hex)	15214e455f5a8320943e012f7a8ced2fe0b9c503
schema:url	https://doi.org/10.1101/2020.06.01.128058
resource representing a document's title	Minimal system for assembly of SARS-CoV-2 virus like particles
schema:publication	bioRxiv
resource representing a document's body	covid:15214e455f5a8320943e012f7a8ced2fe0b9c503#body_text
is schema:about of	named entity 'spherical' named entity 'Atomic Force Microscopy' named entity 'size' named entity 'viral' named entity 'SARS-CoV-2' named entity 'virus' named entity 'ATOMIC FORCE MICROSCOPY' named entity 'SUPPLEMENTARY INFORMATION' named entity 'RETAIN' named entity 'BioRad' named entity 'VLPs' named entity 'VLPs' named entity 'VLPs' named entity 'nanogold' named entity 'VLPs' named entity 'antiviral therapies' named entity 'sucrose' named entity 'CMV' named entity 'VLPs' named entity 'shape' named entity 'Here' named entity 'bovine' named entity 'identical particles' named entity 'virions' named entity 'AFM' named entity 'Protein' named entity 'SARS-CoV-2' named entity 'pathogens' named entity 'atomic force microscopy' named entity 'plasmid' named entity '1:5' named entity 'Non-infectious' named entity 'electron microscopy' named entity 'VLPs' named entity 'mammalian cells' named entity 'protein' named entity 'viruses' named entity 'biochemical' named entity 'VLPs' named entity 'pH 7' named entity 'SARS-CoV-2' named entity 'pandemic disease' named entity 'neutravidin' named entity 'virions' named entity 'molecular weight' named entity 'Cell' named entity 'non-infectious' named entity 'SARS-CoV-2 virus' named entity 'VLPs' named entity 'Atomic Force Microscopy' named entity 'genetic material' named entity 'SDS-PAGE' named entity 'nanogold' named entity 'AFM' named entity 'virions' named entity 'AFM' named entity '293T cells' named entity 'Dallas' named entity 'Thermo Scientific' named entity 'protein' named entity 'SARS-CoV-2' named entity 'PBS' named entity 'protein' named entity 'western blot' named entity 'VLPs' named entity 'western blots' named entity 'VLPs' named entity 'vaccine' named entity 'BCoV' named entity 'VLPs' named entity 'Nitrogen gas' named entity 'SARS-CoV-2 virus' named entity '3.5' named entity 'Bat' named entity 'VLPs' named entity 'Texas' named entity 'carbon'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software