About: Suppression of feline coronavirus replication in vitro by cyclosporin A

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Suppression of feline coronavirus replication in vitro by cyclosporin A
Creator	Inoue, Mai Osawa, Shuichi Sasaki, Takashi Sato, Yuka Tanaka, Satoka Tanaka, Yoshikazu
source	Medline; PMC
abstract	The feline infectious peritonitis virus (FIPV) is a member of the feline coronavirus family that causes FIP, which is incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent that targets the nuclear factor pathway of activated T-cells (NF-AT) to bind cellular cyclophilins (CyP), dose-dependently inhibited FIPV replication in vitro. FK506 (an immunosuppressor of the pathway that binds cellular FK506-binding protein (FKBP) but not CyP) did not affect FIPV replication. Neither cell growth nor viability changed in the presence of either CsA or FK506, and these factors did not affect the NF-AT pathway in fcwf-4 cells. Therefore, CsA does not seem to exert inhibitory effects via the NF-AT pathway. In conclusion, CsA inhibited FIPV replication in vitro and further studies are needed to verify the practical value of CsA as an anti-FIPV treatment in vivo.
has issue date	2012-04-30(xsd:dateTime)
bibo:doi	10.1186/1297-9716-43-41
bibo:pmid	22546085
has license	cc-by
sha1sum (hex)	16283e25f01d47898ad2b82d56bd81d5ccf44a5d
schema:url	https://doi.org/10.1186/1297-9716-43-41
resource representing a document's title	Suppression of feline coronavirus replication in vitro by cyclosporin A
has PubMed Central identifier	PMC3403912
has PubMed identifier	22546085
schema:publication	Vet Res
resource representing a document's body	covid:16283e25f01d47898ad2b82d56bd81d5ccf44a5d#body_text
is schema:about of	named entity 'IN VITRO' named entity 'peritonitis' named entity 'binding' named entity 'FIPV' named entity 'Therefore' named entity 'immunosuppressor' named entity 'FCWF-4' named entity 'NUCLEAR' named entity 'FIP' named entity 'NEITHER' named entity 'BIND' named entity 'FK506-BINDING PROTEIN' named entity 'CSA' named entity 'EXERT' named entity 'CATS' named entity 'THESE' named entity 'IN VITRO' named entity 'MEMBER OF' named entity 'FACTOR' named entity 'EITHER' named entity 'TREATMENT' named entity 'FELINE CORONAVIRUS' named entity 'NEEDED' named entity 'STUDIES' named entity 'CELLS' named entity 'IN VIVO' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'FATAL' named entity 'AFFECT' named entity 'NF-AT' named entity 'CYCLOPHILINS' named entity 'FELINE CORONAVIRUS' named entity 'FK506' named entity 'CONCLUSION' covid:arg/16283e25f01d47898ad2b82d56bd81d5ccf44a5d named entity 'VALUE' named entity 'SUPPRESSION' named entity 'CYCLOSPORIN A' named entity 'TARGETS' named entity 'CAUSES' named entity 'PROTEIN ' named entity 'VIABILITY' named entity 'PATHWAY' named entity 'CELLULAR' named entity 'DOSE' named entity 'PRESENCE OF' named entity 'CHANGED' named entity 'CELL GROWTH' named entity 'INHIBITED' named entity 'DOES NOT' named entity 'IMMUNOSUPPRESSIVE AGENT' named entity 'REPLICATION' named entity 'T-CELLS' named entity 'ACTIVATED' named entity 'BUT' named entity 'VERIFY' named entity 'FAMILY' named entity 'EFFECTS' named entity 'DID' named entity 'CYP' named entity 'IS A' named entity 'INHIBITORY' named entity 'CYCLOSPORIN A' named entity 'FIP' named entity 'FIPV' named entity 'affect' named entity 'targets' named entity 'cell growth' named entity 'cyclosporin A' named entity 'Cyclosporin' named entity 'T-cells' named entity 'FIPV' named entity 'nuclear factor' named entity 'CsA' named entity 'FKBP' named entity 'cell growth'

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