About: DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding

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About: DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding
Creator	Li, Yuan Yang, Xiao Lin, Ling Li, Chun Cheng, Zhi Huang, Zheng, Luo, Ling Wan, Xiao Wu, Wen Zhen, Shu
topic	covid:167caeff381e12ac6cf14497ee14c54253ee13db#this
source	Elsevier; Medline; PMC
abstract	Abstract Viral infections have caused numerous diseases and deaths worldwide. Due to the emergence of new viruses and frequent virus variation, conventional antiviral strategies that directly target viral or cellular proteins are limited because of the specificity, drug resistance and rapid clearance from the human body. Therefore, developing safe and potent antiviral agents with activity against viral infection at multiple points in the viral life cycle remains a major challenge. In this report, we propose a new modality to inhibit viral infection by fabricating DNA conjugated gold nanoparticle (DNA-AuNP) networks on cell membranes as a protective barrier. The DNA-AuNPs networks were found, via a plaque formation assay and viral titers, to have potent antiviral ability and protect host cells from human respiratory syncytial virus (RSV). Confocal immunofluorescence image analysis showed 80 ± 3.8% of viral attachment, 91.1 ± 0.9% of viral entry and 87.9 ± 2.8% of viral budding were inhibited by the DNA-AuNP networks, which were further confirmed by real-time fluorescence imaging of the RSV infection process. The antiviral activity of the networks may be attributed to steric effects, the disruption of membrane glycoproteins and limited fusion of cell membrane bilayers, all of which play important roles in viral infection. Therefore, our results suggest that the DNA-AuNP networks have not only prophylactic effects to inhibit virus attachment and entry, but also therapeutic effects to inhibit viral budding and cell-to-cell spread. More importantly, this proof-of-principle study provides a pathway for the development of a universal, broad-spectrum antiviral therapy.
has issue date	2016-01-31(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2015.11.008
bibo:pmid	26606447
has license	els-covid
sha1sum (hex)	167caeff381e12ac6cf14497ee14c54253ee13db
schema:url	https://doi.org/10.1016/j.biomaterials.2015.11.008
resource representing a document's title	DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding
has PubMed Central identifier	PMC7112435
has PubMed identifier	26606447
schema:publication	Biomaterials
resource representing a document's body	covid:167caeff381e12ac6cf14497ee14c54253ee13db#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/167caeff381e12ac6cf14497ee14c54253ee13db
is schema:about of	named entity 'networks' named entity 'bilayers' named entity 'cells' named entity 'antiviral' named entity 'conjugated' named entity 'RSV infection' named entity 'CELL' named entity 'VIRUS' named entity 'L S' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'MULTIPLE' named entity 'N A' named entity 'PLAY' named entity 'EFFECTS' named entity 'BUDDING' named entity 'UNIVERSAL' named entity 'VIRAL ENTRY' named entity 'ROLES' named entity 'NUMEROUS' named entity 'DRUG RESISTANCE' named entity 'PLAQUE' named entity 'VIRAL INFECTIONS' named entity 'DNA' named entity 'ANTIVIRAL ACTIVITY' named entity 'GOLD NANOPARTICLE' named entity 'THERAPEUTIC' named entity 'HOST CELLS' named entity 'A T' named entity 'HUMAN BODY' named entity 'FORMATION' named entity 'NETWORKS' named entity 'RSV INFECTION' named entity 'CHALLENGE' named entity 'MEMBRANE GLYCOPROTEINS' named entity 'PROTEINS' named entity 'TO INHIBIT' named entity 'SAFE' named entity 'RAPID' named entity 'DEVELOPING' named entity 'SPREAD' named entity 'TO INHIBIT' named entity 'CELL MEMBRANES' named entity 'VIRAL ATTACHMENT' named entity 'AUNP' named entity 'ON CELL' named entity 'SPECTRUM' named entity 'ANTIVIRAL AGENTS' named entity 'VIRUS ATTACHMENT' named entity 'CELLULAR' named entity 'IMMUNOFLUORESCENCE' named entity '0.9' named entity 'NEW' named entity 'PROOF' named entity 'VIRAL ATTACHMENT' named entity 'CONJUGATED' named entity 'CELL MEMBRANES' named entity 'STRATEGIES' named entity 'TARGET' named entity 'VIRAL INFECTION' named entity 'L H' named entity 'HAVE' named entity 'ENTRY' named entity 'ANTIVIRAL' named entity 'VARIATION' named entity 'VIRAL' named entity 'RESULTS' named entity 'FUSION' named entity 'PROVIDES' named entity 'ACTIVITY'

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