About: Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication

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About: Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication
Creator	Rodriguez, Luis Baxt, Barry Burrage, Tom Jackson, William Larocco, Michael Pacheco, Juan Borca, Manuel O'donnell, Vivian
topic	covid:1954505b8d34d065e8140c40db252d0e21fe4bb0#this
Source	Elsevier; Medline; PMC
abstract	Abstract Foot-and-mouth disease virus (FMDV) is the type species of the Aphthovirus genus within the Picornaviridae family. Infection of cells with positive-strand RNA viruses results in a rearrangement of intracellular membranes into viral replication complexes. The origin of these membranes remains unknown; however induction of the cellular process of autophagy is beneficial for the replication of poliovirus, suggesting that it might be advantageous for other picornaviruses. By using confocal microscopy we showed in FMDV-infected cells co-localization of non-structural viral proteins 2B, 2C and 3A with LC3 (an autophagosome marker) and viral structural protein VP1 with Atg5 (autophagy-related protein), and LC3 with LAMP-1. Importantly, treatment of FMDV-infected cell with autophagy inducer rapamycin, increased viral yield, and inhibition of autophagosomal pathway by 3-methyladenine or small-interfering RNAs, decreased viral replication. Altogether, these studies strongly suggest that autophagy may play an important role during the replication of FMDV.
has issue date	2011-02-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.10.042
bibo:pmid	21112602
has license	els-covid
sha1sum (hex)	1954505b8d34d065e8140c40db252d0e21fe4bb0
schema:url	https://doi.org/10.1016/j.virol.2010.10.042
resource representing a document's title	Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication
has PubMed Central identifier	PMC7126820
has PubMed identifier	21112602
schema:publication	Virology
resource representing a document's body	covid:1954505b8d34d065e8140c40db252d0e21fe4bb0#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1954505b8d34d065e8140c40db252d0e21fe4bb0
is schema:about of	named entity 'complexes' named entity 'viral replication' named entity 'PATHWAY' named entity 'USING' named entity 'CELLULAR PROCESS' named entity 'CO-LOCALIZATION' named entity 'POSITIVE' named entity 'MIGHT BE' named entity 'MEMBRANES' named entity 'VIRAL' named entity 'PATHWAY' named entity 'FMDV' covid:arg/1954505b8d34d065e8140c40db252d0e21fe4bb0 named entity 'IMPORTANT' named entity 'REARRANGEMENT' named entity 'SPECIES' named entity 'VIRAL PROTEINS' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'VIRAL REPLICATION' named entity 'STRUCTURAL' named entity 'CELLS' named entity 'PLAY' named entity 'ORIGIN' named entity 'GENUS' named entity 'INCREASED' named entity 'ATG5' named entity 'PICORNAVIRIDAE' named entity 'INTERFERING' named entity 'INHIBITION' named entity 'THESE' named entity 'RELATED' named entity 'YIELD' named entity 'BENEFICIAL' named entity 'AUTOPHAGOSOME' named entity 'NON-' named entity 'SMALL' named entity 'FAMILY' named entity 'CONFOCAL MICROSCOPY' named entity 'VIRAL REPLICATION' named entity 'INFECTED' named entity 'AUTOPHAGY' named entity 'RESULTS' named entity 'PROTEIN ' named entity 'RNAS' named entity 'UNKNOWN' named entity 'VP1' named entity 'LC3' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'APHTHOVIRUS' named entity 'STRUCTURAL PROTEIN' named entity '3-METHYLADENINE' named entity 'LAMP-1' named entity 'SUGGEST' named entity 'PROTEIN' named entity 'OTHER PICORNAVIRUSES' named entity 'MARKER' named entity 'ROLE' named entity 'TREATMENT' named entity 'TYPE' named entity 'COMPLEXES' named entity 'RAPAMYCIN' named entity 'INFECTION' named entity 'INTRACELLULAR MEMBRANES' named entity 'INDUCTION' named entity 'INFECTED CELL' named entity 'STRAND' named entity 'POLIOVIRUS' named entity 'REPLICATION' named entity 'DECREASED' named entity 'RNA VIRUSES' named entity 'AUTOPHAGY INDUCER' named entity 'STUDIES'

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