About: Integration of the Gene Ontology into an object-oriented architecture

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Integration of the Gene Ontology into an object-oriented architecture
Creator	Shegogue, Daniel Zheng, Jim
Source	Medline; PMC
abstract	BACKGROUND: To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological processes, molecular functions, and cellular components. However, there is no single representation that integrates all the terms into one cohesive model. Furthermore, GO definitions have little information explaining the underlying architecture that forms these terms, such as the dynamic and static events occurring in a process. In contrast, object-oriented models have been developed to show dynamic and static events. A portion of the TGF-beta signaling pathway, which is involved in numerous cellular events including cancer, differentiation and development, was used to demonstrate the feasibility of integrating the Gene Ontology into an object-oriented model. RESULTS: Using object-oriented models we have captured the static and dynamic events that occur during a representative GO process, %22transforming growth factor-beta (TGF-beta) receptor complex assembly%22 (GO:0007181). CONCLUSION: We demonstrate that the utility of GO terms can be enhanced by object-oriented technology, and that the GO terms can be integrated into an object-oriented model by serving as a basis for the generation of object functions and attributes.
has issue date	2005-05-10(xsd:dateTime)
bibo:doi	10.1186/1471-2105-6-113
bibo:pmid	15885145
has license	cc-by
sha1sum (hex)	198ed53d956a2707716d175cc6516bb720f52d82
schema:url	https://doi.org/10.1186/1471-2105-6-113
resource representing a document's title	Integration of the Gene Ontology into an object-oriented architecture
has PubMed Central identifier	PMC1156866
has PubMed identifier	15885145
schema:publication	BMC Bioinformatics
resource representing a document's body	covid:198ed53d956a2707716d175cc6516bb720f52d82#body_text
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