About: GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus

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About: GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus
Creator	Chang, Jinhong Guo, Ju-Tao Zhang, Yue Zhao, Xuesen Li, Rui Zheng, Mei Zeng, Hui Jiang, Dong Hou, Zhifei Lin, Hanxin Chen, Danying Li, Guoli
source	Medline; PMC
abstract	Interferons (IFNs) control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. We report herein that gamma-interferon-inducible lysosomal thiol reductase (GILT), a lysosome-associated ISG, restricts the infectious entry of selected enveloped RNA viruses. Specifically, we demonstrated that GILT was constitutively expressed in lung epithelial cells and fibroblasts and its expression could be further induced by type II interferon. While overexpression of GILT inhibited the entry mediated by envelope glycoproteins of SARS coronavirus (SARS-CoV), Ebola virus (EBOV) and Lassa fever virus (LASV), depletion of GILT enhanced the entry mediated by these viral envelope glycoproteins. Furthermore, mutations that impaired the thiol reductase activity or disrupted the N-linked glycosylation, a posttranslational modification essential for its lysosomal localization, largely compromised GILT restriction of viral entry. We also found that the induction of GILT expression reduced the level and activity of cathepsin L, which is required for the entry of these RNA viruses in lysosomes. Our data indicate that GILT is a novel antiviral ISG that specifically inhibits the entry of selected enveloped RNA viruses in lysosomes via disruption of cathepsin L metabolism and function and may play a role in immune control and pathogenesis of these viruses.
has issue date	2019-10-21(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1677446
bibo:pmid	31631785
has license	cc-by
sha1sum (hex)	19df6a2ae9a9070dd15404465eed98ad222b27f0
schema:url	https://doi.org/10.1080/22221751.2019.1677446
resource representing a document's title	GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus
has PubMed Central identifier	PMC6818130
has PubMed identifier	31631785
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:19df6a2ae9a9070dd15404465eed98ad222b27f0#body_text
is schema:about of	named entity 'RESTRICT' named entity 'DEPLETION' named entity 'INFECTIOUS' named entity 'FIBROBLASTS' named entity 'GILT' named entity 'INDUCED' named entity 'COULD BE' named entity 'STEPS' named entity 'FUNCTION' named entity 'EPITHELIAL CELLS' named entity 'VIRAL ENTRY' named entity 'VIRAL ENVELOPE' named entity 'LYSOSOMES' named entity 'PLAY' named entity 'ENHANCED' named entity 'MEDIATED' named entity 'ISG' named entity 'ITS' named entity 'ROLE' named entity 'OVEREXPRESSION' named entity 'selected' named entity 'mutations' named entity 'viruses' named entity 'restrict' named entity 'metabolism' named entity 'cellular' named entity 'RESTRICTS' named entity 'LYSOSOMAL' named entity 'METABOLISM ' named entity 'DISRUPTED' named entity 'INDUCTION' named entity 'INHIBITED' named entity 'ENTRY' named entity 'ESSENTIAL' named entity 'STIMULATED' named entity 'INDUCING' named entity 'FOUND' named entity 'IS A' named entity 'NOVEL' named entity 'LARGELY' named entity 'TYPE II INTERFERON' named entity 'REDUCED' named entity 'THIOL' named entity 'MUTATIONS' named entity 'ENVELOPE' named entity 'DISRUPTION' named entity 'THESE' named entity 'CELLULAR' named entity 'GILT' named entity 'GLYCOPROTEINS' named entity 'ENVELOPE' named entity 'EBOLA VIRUS' named entity 'SARS-COV' named entity 'LASSA FEVER VIRUS' named entity 'VIRAL INFECTIONS' named entity 'EXPRESSED' named entity 'POSTTRANSLATIONAL MODIFICATION' named entity 'VIRAL REPLICATION' named entity 'LOCALIZATION' named entity 'CATHEPSIN L' named entity 'INTERFERONS' named entity 'OUR' named entity 'ANTIVIRAL' named entity 'IMPAIRED' named entity 'DISTINCT' named entity 'PATHOGENESIS' named entity 'EXPRESSION' named entity 'IFN' named entity 'EBOLA VIRUS' named entity 'RESTRICTION'

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