About: Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis

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About: Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis
Creator	Richard, A Tulasne, D
Source	Medline; PMC
abstract	Viral infection constitutes an unwanted intrusion that needs to be eradicated by host cells. On one hand, one of the first protective barriers set up to prevent viral replication, spread or persistence involves the induction of apoptotic cell death that aims to limit the availability of the cellular components for viral amplification. On the other hand, while they completely depend on the host molecular machinery, viruses also need to evade the cellular responses that are meant to destroy them. The existence of numerous antiapoptotic products within the viral kingdom proves that apoptosis constitutes a major threat that should better be bypassed. Among the different strategies developed to deal with apoptosis, one is based on what viruses do best: backfiring the cell on itself. Several unrelated viruses have been described to take advantage of apoptosis induction by expressing proteins targeted by caspases, the key effectors of apoptotic cell death. Caspase cleavage of these proteins results in various consequences, from logical apoptosis inhibition to more surprising enhancement or attenuation of viral replication. The present review aims at discussing the characterization and relevance of this post-translational modification that adds a new complexity in the already intricate host–apoptosis–virus triangle.
has issue date	2012-03-08(xsd:dateTime)
bibo:doi	10.1038/cddis.2012.18
bibo:pmid	22402601
has license	cc-by-nc-nd
sha1sum (hex)	1a6e69772e4e79d9106015988c0d6ed48dc25ceb
schema:url	https://doi.org/10.1038/cddis.2012.18
resource representing a document's title	Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis
has PubMed Central identifier	PMC3317351
has PubMed identifier	22402601
schema:publication	Cell Death Dis
resource representing a document's body	covid:1a6e69772e4e79d9106015988c0d6ed48dc25ceb#body_text
is schema:about of	named entity 'BEST' named entity 'KINGDOM' named entity 'MEANT' named entity 'BASED' named entity 'DIFFERENT' named entity 'COMPONENTS' named entity 'NEW' named entity 'LIMIT' named entity 'HOST CELLS' named entity 'PROTEINS' named entity 'NEEDS' named entity 'KEY' named entity 'VIRAL' named entity 'VARIOUS' named entity 'AIMS' named entity 'VIRUS' named entity 'CASPASES' named entity 'TRIANGLE' named entity 'INDUCTION' named entity 'REVIEW' named entity 'DESTROY' named entity 'VIRUSES' named entity 'PERSISTENCE' named entity 'MOLECULAR' named entity 'APOPTOTIC CELL DEATH' named entity 'TARGETED' named entity 'expressing' named entity 'limit' named entity 'viral replication' named entity 'existence' named entity 'numerous' named entity 'CASPASE' named entity 'MAKE' named entity 'APOPTOSIS INHIBITION' named entity 'NUMEROUS' named entity 'VIRAL INFECTION' named entity 'CELLULAR' named entity 'TO TAKE' named entity 'BEST' named entity 'VIRAL REPLICATION' named entity 'RELEVANCE' named entity 'WAY' named entity 'VIRAL PROTEINS' named entity 'APOPTOSIS' named entity 'THESE' named entity 'CLEAVAGE' named entity 'ENHANCEMENT' named entity 'INTRUSION' named entity 'NEED' named entity 'COMPLETELY' named entity 'RESULTS' named entity 'UP TO' named entity 'CONSEQUENCES' named entity 'THREAT' named entity 'SET UP' named entity 'ANTIAPOPTOTIC' named entity 'RESPONSES' named entity 'A MAJOR' named entity 'CASPASE' named entity 'CHARACTERIZATION' named entity 'MACHINERY' named entity 'COMPLEXITY' named entity 'HAVE' named entity 'STRATEGIES' named entity 'PRODUCTS' named entity 'DEAL' named entity 'HAND' named entity 'DEPEND' named entity 'ATTENUATION' named entity 'PRESENT' named entity 'VIRUSES' named entity 'CLEAVAGE' named entity 'TO PREVENT' named entity 'DESCRIBED' named entity 'APOPTOSIS INDUCTION' named entity 'AVAILABILITY OF' named entity 'BETTER' named entity 'WHAT' named entity 'THE CELL' named entity 'AMPLIFICATION'

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