About: Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis

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About: Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis
Creator	Mattiello, Rita Jones, Marcus Sarria, Edgar Stein, Renato Comerlato Scotta, Marcelo Coutinho, Valentina De Moura, Angela Duarte De Souza, Ana Garces Becker, Rafaela Gava Chakr, Baldoto Marcio Pitrez, Paulo Pinto, Leonardo
source	Elsevier; Medline; PMC
abstract	BACKGROUND: With advent of molecular diagnostic technologies, studies have reported detection of two or more respiratory viruses in about 30% of children with respiratory infections. However, prognostic role of coinfection remains unclear. OBJECTIVE: Evaluate relation between respiratory viral confection and illness severity in children. STUDY DESIGN: MEDLINE (through PUBMED), EMBASE, EBSCO, LILACS databases were searched up to March 2015 by two independent reviewers. Studies assessing severity of viral coinfection in patients aged less than 18 years were included. Standardized forms were used for data extraction of population, study design, clinical syndromes, virus combinations compared and severity outcomes. Risk of bias and quality of evidence were assessed through EPHPP and GRADE. Subgroup analysis was performed according to age and viral combinations. RESULTS: Of 5218 records screened, 43 were included in analysis. Viral coinfection did not influence risks of all outcomes assessed: length of stay (mean difference in days in coinfection, −0.10 [95% confidence interval: −0.51 to 0.31]), length of supplemental oxygen (−0.42 [−1.05 to 0.20]), need of hospitalization (odds ratio of coinfection, 0.96 [95% confidence interval: 0.61–1.51]), supplemental oxygen (0.94 [0.66 to 1.34]), need of intensive care (0.99 [0.64 to 1.54]), mechanical ventilation (0.81 [0.33 to 2.01]) and death (2.22 [0.83 to 5.95]). Sub-analyses according to age and viral combinations have not shown influence of these factors in outcomes. CONCLUSIONS: Respiratory viral coinfection did not increase severity in all outcomes assessed. Further studies are necessary to confirm this finding, especially regarding role of specific viral interactions.
has issue date	2016-04-30(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2016.04.019
bibo:pmid	27155055
has license	no-cc
sha1sum (hex)	1af946e7a63239d9b462e126f98d0cd6d24df4bd
schema:url	https://doi.org/10.1016/j.jcv.2016.04.019
resource representing a document's title	Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis
has PubMed Central identifier	PMC7185664
has PubMed identifier	27155055
schema:publication	J Clin Virol
resource representing a document's body	covid:1af946e7a63239d9b462e126f98d0cd6d24df4bd#body_text
is schema:about of	named entity 'VIRAL' named entity 'DATA EXTRACTION' named entity 'AGE' named entity 'PATIENTS' named entity '920' named entity 'CLINICAL SYNDROMES' named entity 'ILLNESS SEVERITY' named entity 'AGED' named entity 'TWO OR MORE' named entity '1.34' named entity '2015' named entity 'VIRUS' named entity 'YEARS' named entity 'OUTCOMES' named entity 'UNCLEAR' named entity 'POPULATION' named entity 'LENGTH' named entity 'SEVERITY' named entity 'INTENSIVE CARE' named entity '282' named entity 'RECORDS' named entity 'PUBMED' named entity 'respiratory' named entity 'assessing' named entity 'databases' named entity 'advent' named entity 'Study design' named entity 'REMAINS' named entity 'META-ANALYSIS' named entity 'CHILDREN' named entity 'ANALYSIS' named entity 'QUALITY OF EVIDENCE' named entity 'MEDLINE' named entity 'SUPPLEMENTAL OXYGEN' named entity 'COINFECTION' named entity 'ABOUT' named entity 'SEARCHED' named entity 'NECESSARY' named entity 'RESPIRATORY VIRUSES' named entity 'PROGNOSTIC' named entity 'CONCLUSIONS' named entity 'FINDING' named entity 'DISEASE SEVERITY' named entity 'SYSTEMATIC REVIEW' named entity 'COINFECTION' named entity 'PERFORMED' named entity 'STUDY DESIGN' named entity 'RESPIRATORY' named entity 'SPECIFIC' named entity 'COMBINATIONS' named entity 'TECHNOLOGIES' named entity 'RISK OF BIAS' named entity 'DATABASES' named entity 'NEED' named entity 'DEATH' named entity 'SUBGROUP ANALYSIS' named entity 'BACKGROUND' named entity 'CONFIDENCE INTERVAL' named entity 'VIRAL' named entity 'INCREASE' named entity 'INDEPENDENT' named entity 'ASSESSING' named entity 'USED' named entity 'RESPIRATORY' named entity 'REPORTED' named entity '20%' named entity 'FORMS' named entity 'LENGTH OF STAY' named entity '921' named entity 'ROLE'

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