About: Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin

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About: Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin
Creator	Bartenschlager, Ralf Carrasco, Luis Madan, Vanesa Nieva, José
source	Medline; PMC
abstract	The high prevalence of hepatitis C virus (HCV) infection in the human population has triggered intensive research efforts that have led to the development of curative antiviral therapy. Moreover, HCV has become a role model to study fundamental principles that govern the replication cycle of a positive strand RNA virus. In fact, for most HCV proteins high-resolution X-ray and NMR (Nuclear Magnetic Resonance)-based structures have been established and profound insights into their biochemical and biological properties have been gained. One example is p7, a small hydrophobic protein that is dispensable for RNA replication, but crucial for the production and release of infectious HCV particles from infected cells. Owing to its ability to insert into membranes and assemble into homo-oligomeric complexes that function as minimalistic ion channels, HCV p7 is a member of the viroporin family. This review compiles the most recent findings related to the structure and dual pore/ion channel activity of p7 of different HCV genotypes. The alternative conformations and topologies proposed for HCV p7 in its monomeric and oligomeric state are described and discussed in detail. We also summarize the different roles p7 might play in the HCV replication cycle and highlight both the ion channel/pore-like function and the additional roles of p7 unrelated to its channel activity. Finally, we discuss possibilities to utilize viroporin inhibitors for antagonizing p7 ion channel/pore-like activity.
has issue date	2015-08-06(xsd:dateTime)
bibo:doi	10.3390/v7082826
bibo:pmid	26258788
has license	cc-by
sha1sum (hex)	1c07f420a5a01bec7481025a89f2621596a99782
schema:url	https://doi.org/10.3390/v7082826
resource representing a document's title	Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin
has PubMed Central identifier	PMC4576187
has PubMed identifier	26258788
schema:publication	Viruses
resource representing a document's body	covid:1c07f420a5a01bec7481025a89f2621596a99782#body_text
is schema:about of	named entity 'dual' named entity 'topologies' named entity 'conformations' named entity 'HEPATITIS C VIRUS' named entity 'STRUCTURAL' named entity 'ION CHANNELS' named entity 'DISCUSS' named entity 'MEMBER OF' named entity 'RELATED' named entity 'THEIR' named entity 'PROTEIN ' named entity 'ADDITIONAL' named entity 'UNRELATED' named entity 'PLAY' named entity 'SMALL' named entity 'FINDINGS' named entity 'INFECTED' named entity 'POSITIVE STRAND RNA VIRUS' named entity 'PARTICLES' named entity 'HAVE' named entity 'NMR' named entity 'LED' named entity 'STRUCTURE' named entity 'PORE' named entity 'PROPOSED' named entity 'PROFOUND' named entity 'HUMAN POPULATION' named entity 'ANTIVIRAL THERAPY' named entity 'GAINED' named entity 'DIFFERENT' named entity 'DUAL' named entity 'BIOLOGICAL PROPERTIES' named entity 'GENOTYPES' named entity 'RESEARCH' named entity 'INSERT' named entity 'ESTABLISHED' named entity 'VIROPORIN' named entity 'PROPERTIES' named entity 'CHANNEL ACTIVITY' named entity 'STRUCTURES' named entity 'REPLICATION CYCLE' named entity 'HCV' named entity 'FAMILY' named entity 'PRODUCTION' named entity 'STATE' named entity 'INFECTIOUS' named entity 'ACTIVITY' named entity 'ASSEMBLE' named entity 'INSIGHTS' named entity 'HEPATITIS C VIRUS' named entity 'MOST RECENT' named entity 'X-RAY' named entity 'HOMO' named entity 'BUT' named entity 'ROLES' named entity 'PROTEINS' named entity 'ALTERNATIVE' named entity 'STUDY' named entity 'HIGH PREVALENCE' named entity 'ITS' named entity 'VIROPORIN' named entity 'ION CHANNEL' named entity 'EXAMPLE' named entity 'BASED' named entity 'MEMBRANES' named entity 'MAGNETIC RESONANCE' named entity 'DESCRIBED' named entity 'RNA REPLICATION' named entity 'RELEASE' named entity 'IS A' named entity 'DEVELOPMENT' named entity 'COMPLEXES' named entity 'FUNCTIONAL' named entity 'HYDROPHOBIC PROTEIN' named entity 'INFECTION' named entity 'FUNCTION' named entity 'CURATIVE' named entity 'INHIBITORS'

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