About: Effects of acute and chronic dimethylamine exposure on the nasal mucociliary apparatus of F-344 rats

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of acute and chronic dimethylamine exposure on the nasal mucociliary apparatus of F-344 rats
Creator	Gross, E Morgan, K Patterson, D Toxicologyandappliedpharh3acology~, ;
Source	Elsevier; Medline; PMC
abstract	Abstract Dimethylamine (DMA) is a highly water soluble gas with many industrial applications. Male F-344 rats were exposed to 175 ppm DMA 6 hr per day for 1, 2, 4, or 9 days or 2 years. Gross changes in nasal structure were recorded, effects of DMA on the mucociliary apparatus were assessed using video analysis, and tissues were evaluated for histopathology. In vitro nasal mucociliary flow patterns, mucus flow rates, and ciliary activity were studied and recorded for video motion analysis. There were distinct and generally consistent differences in the shape of the naso-, maxillo-, and ethmoid turbinates between young and old animals. Acute and chronic DMA exposures resulted in erosion of the anterior margins of the naso- and maxillo-turbinates and fenestration of the adjacent septum. Ciliastasis and mucostasis were observed only on the anteromedial aspect of the maxilloturbinate. In the chronically exposed rats, mucociliary activity was present in areas adjacent to erosions of the turbinates and septum. Abnormal mucus flow patterns, including altered or reversed direction of flow and “whirlpool-like” formation, were observed in all treated rats, but were more severe following chronic exposure. There was a good correlation between the distribution of responses as assessed by histopathology and abnormal mucociliary function at all time points. In conclusion, the mucociliary apparatus continues to function in the nasal passages of rats having localized destruction of nasal epithelium, induced by DMA exposure, and this clearance system responds to alterations of nasal structure by modification of mucus flow patterns.
has issue date	1987-09-30(xsd:dateTime)
bibo:doi	10.1016/0041-008x(87)90129-3
bibo:pmid	3660407
has license	els-covid
sha1sum (hex)	1ce554ce77c36f55fa3aaffc522013236fb9cb6b
schema:url	https://doi.org/10.1016/0041-008x%2887%2990129-3
resource representing a document's title	Effects of acute and chronic dimethylamine exposure on the nasal mucociliary apparatus of F-344 rats
has PubMed Central identifier	PMC7130120
has PubMed identifier	3660407
schema:publication	Toxicology and Applied Pharmacology
resource representing a document's body	covid:1ce554ce77c36f55fa3aaffc522013236fb9cb6b#body_text
is schema:about of	named entity 'altered' named entity 'tissues' named entity 'histopathology' named entity 'histopathology' named entity 'video analysis' named entity 'formation' named entity 'fenestration' named entity 'Effects' named entity 'EFFECTS' named entity 'INDUCED' named entity 'NASAL' named entity 'AREAS' named entity 'GOOD' named entity 'TREATED' named entity 'ANTERIOR' named entity '2C4' named entity 'FORMATION' named entity 'CONSISTENT' named entity 'CORRELATION' named entity 'FOLLOWING' named entity 'INDUSTRIAL APPLICATIONS' named entity 'EVALUATED' named entity 'YOUNG' named entity 'USING' named entity 'ASSESSED' named entity 'DMA' named entity '344' named entity 'EROSIONS' named entity 'FLOW RATES' named entity 'EXPOSURE' named entity 'SHAPE' named entity 'EXPOSED TO' named entity 'ADJACENT TO' named entity 'CHRONIC EXPOSURE' named entity 'FLOW' named entity 'ALTERED' named entity 'FUNCTION' named entity 'CONCLUSION' named entity 'RESPONDS' named entity 'CHRONIC' named entity 'RECORDED' named entity 'PPM' named entity 'CHANGES' named entity 'ABNORMAL MUCUS' named entity 'RATS' named entity 'EXPOSURES' named entity 'CLEARANCE' named entity 'MODIFICATION' named entity 'SEPTUM' named entity 'NASAL' named entity 'YEARS' named entity 'DIMETHYLAMINE' named entity 'REVERSED' named entity 'VIDEO' named entity 'OLD' named entity 'APPARATUS' named entity 'IS A' named entity 'ACADEMIC' named entity 'SYSTEM' named entity 'DISTRIBUTION' named entity 'RESPONSES' named entity 'WAS A' named entity 'SEVERE' named entity 'OBSERVED' named entity 'MOTION' named entity 'INCLUDING' named entity 'MALE' named entity 'ANIMALS' named entity 'ANALYSIS' named entity 'LOCALIZED' named entity 'PRESENT' named entity 'NASO' named entity 'ACUTE' named entity 'ETHMOID' named entity 'ACUTE' named entity 'RATS' named entity 'POINTS' named entity 'NASAL STRUCTURE'

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