About: To clear or to fear: An innate perspective on factor VIII immunity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: To clear or to fear: An innate perspective on factor VIII immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	To clear or to fear: An innate perspective on factor VIII immunity
Creator	Hough, Christine Lillicrap, David Georgescu, Maria Lai, Jesse
source	Elsevier; Medline; PMC
abstract	Abstract The enigma that is factor VIII immunogenicity remains ever pertinent in the treatment of hemophilia A. Development of neutralizing antibodies against the therapeutic protein in 25–30% of patients likely depends on the appropriate activation of the innate immune response shortly following antigen encounter. Our understanding of this important immunological synapse remains ill-defined. In this review, we examine the three distinct factors contributing to the fate of factor VIII almost immediately after infusion: the characteristics of the protein, the cell, and the microenvironment. We propose a continuum between clearance and antigen presentation that facilitates removal of FVIII from circulation leading to either tolerance or immunity.
has issue date	2016-03-31(xsd:dateTime)
bibo:doi	10.1016/j.cellimm.2015.10.011
bibo:pmid	26547364
has license	els-covid
sha1sum (hex)	1ceb06442e398bebe0381399dbc65e4c3c512ae4
schema:url	https://doi.org/10.1016/j.cellimm.2015.10.011
resource representing a document's title	To clear or to fear: An innate perspective on factor VIII immunity
has PubMed Central identifier	PMC7124272
has PubMed identifier	26547364
schema:publication	Cellular Immunology
resource representing a document's body	covid:1ceb06442e398bebe0381399dbc65e4c3c512ae4#body_text
is schema:about of	named entity 'FACTOR VIII' named entity 'PERSPECTIVE' named entity 'pertinent' named entity 'antigen' named entity 'innate' named entity 'IMMUNITY' named entity 'ENCOUNTER' named entity 'REVIEW' named entity 'THE CELL' named entity 'OUR' named entity 'TOLERANCE' named entity 'APPROPRIATE' named entity 'ILL-DEFINED' named entity 'LEADING' named entity 'HEMOPHILIA A' named entity 'CLEARANCE' named entity 'IMMEDIATELY' named entity 'IMMUNOGENICITY' named entity 'INNATE IMMUNE RESPONSE' named entity 'PROTEIN ' named entity 'PATIENTS' named entity 'CLEAR' named entity 'FEAR' named entity 'CIRCULATION' named entity 'IMPORTANT' named entity 'ENIGMA' named entity 'ALMOST' named entity 'FVIII' named entity 'INFUSION' named entity 'UNDERSTANDING' named entity 'IMMUNITY' named entity 'THERAPEUTIC PROTEIN' named entity 'ACTIVATION' named entity 'TREATMENT' named entity 'DEVELOPMENT' named entity 'LIKELY' named entity 'ANTIGEN' named entity 'FACTOR VIII' named entity 'EITHER' named entity 'PROTEIN' named entity 'FOLLOWING' named entity 'NEUTRALIZING ANTIBODIES' named entity '30%' named entity 'FATE' named entity 'MICROENVIRONMENT' named entity 'CHARACTERISTICS' named entity 'DISTINCT' named entity 'IMMUNOLOGICAL SYNAPSE' named entity 'CONTRIBUTING' named entity 'ANTIGEN PRESENTATION' named entity 'REMOVAL' named entity 'factors' named entity 'tolerance' named entity 'microenvironment' named entity 'factor VIII' named entity 'infusion' named entity 'hemophilia' named entity 'protein' named entity 'factor VIII' named entity 'liver' named entity 'immune response' named entity 'IgG4' named entity 'ligand-binding' named entity 'co-stimulatory molecules' named entity 'cytokines' named entity 'glycans' named entity 'antibodies' named entity 'alloantibodies' named entity 'APCs' named entity 'interferon-gamma' named entity 'immune response' named entity 'red meat' named entity 'antigen presentation' named entity 'VWF' named entity 'immune response' named entity 'prophylactic' named entity 'peptides' named entity 'secretion'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software