About: Novel Virus Influenza A (H1N1sw) in South-Eastern France, April-August 2009

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About: Novel Virus Influenza A (H1N1sw) in South-Eastern France, April-August 2009 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel Virus Influenza A (H1N1sw) in South-Eastern France, April-August 2009
Creator	Raoult, Didier Ninove, Laetitia Salez, Nicolas De Lamballerie, Xavier Zandotti, Christine Mantey, Karine Charrel, N Cé Line Gazin, Mie Resseguier, Noé Nougairè De, Antoine Ré,
source	Medline; PMC
abstract	BACKGROUND: In April 2009, the first cases of pandemic (H1N1)-2009 influenza [H1N1sw] virus were detected in France. Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones. METHODOLOGY/PRINCIPAL FINDINGS: We report results of virological analyses performed in the Public Hospitals of Marseille during the first months of the outbreak. (i) Nasal swabs were tested using rapid influenza diagnostic test (RIDT) and two RT-PCR assays. Epidemiological characteristics of the 99 first suspected cases were analyzed, including detection of influenza virus and 18 other respiratory viruses. During three months, a total of 1,815 patients were tested (including 236 patients infected H1N1sw virus) and distribution in age groups and results of RIDT were analyzed. (ii) 600 sera received before April 2009 and randomly selected from in-patients were tested by a standard hemagglutination inhibition assay for antibody to the novel H1N1sw virus. (iii) One early (May 2009) and one late (July 2009) viral isolates were characterized by sequencing the complete hemagglutinine and neuraminidase genes. (iiii) Epidemiological characteristics of a cluster of cases that occurred in July 2009 in a summer camp were analyzed. CONCLUSIONS/SIGNIFICANCE: This study presents new virological and epidemiological data regarding infection by the pandemic A/H1N1 virus in Europe. Distribution in age groups was found to be similar to that previously reported for seasonal H1N1. The first seroprevalence data made available for a European population suggest a previous exposure of individuals over 40 years old to influenza viruses antigenically related to the pandemic (H1N1)-2009 virus. Genomic analysis indicates that strains harbouring a new amino-acid pattern in the neuraminidase gene appeared secondarily and tended to supplant the first strains. Finally, in contrast with previous reports, our data support the use of RIDT for the detection of infection in children, especially in the context of the investigation of grouped cases.
has issue date	2010-02-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0009214
bibo:pmid	20174643
has license	cc-by
sha1sum (hex)	1cf0ff471514dc73eaa490d65d0d4a35f1345f6e
schema:url	https://doi.org/10.1371/journal.pone.0009214
resource representing a document's title	Novel Virus Influenza A (H1N1sw) in South-Eastern France, April-August 2009
has PubMed Central identifier	PMC2822845
has PubMed identifier	20174643
schema:publication	PLoS One
resource representing a document's body	covid:1cf0ff471514dc73eaa490d65d0d4a35f1345f6e#body_text
is schema:about of	named entity 'H1N1' named entity 'FRENCH' named entity 'PANDEMIC' named entity 'FRANCE' named entity 'SEVEN' named entity 'REFERENCE' named entity 'LABORATORIES' named entity 'SOUTH' named entity 'INFLUENZA' named entity 'NOVEL' named entity 'VIRUS' named entity 'SURVEILLANCE' named entity 'BACKGROUND' named entity 'EASTERN' named entity 'DETECTED' named entity 'VIROLOGICAL' named entity 'APRIL' named entity 'INFLUENZA A' named entity 'VIRUS INFLUENZA' named entity 'CASES' covid:arg/1cf0ff471514dc73eaa490d65d0d4a35f1345f6e named entity 'French Defence' named entity 'reference' named entity '2009' named entity 'virus' named entity 'Influenza' named entity 'Virus' named entity 'viral load' named entity 'antibodies' named entity 'H3N2' named entity 'virus' named entity 'antibodies' named entity 'enteroviruses' named entity 'RT-PCR' named entity 'Statistical analysis' named entity 'virus' named entity 'Antibodies' named entity 'amino-acids' named entity 'Mexico' named entity 'antibody' named entity 'nucleotide' named entity 'serological' named entity 'antibodies' named entity 'infection' named entity 'influenza' named entity 'antibody' named entity 'asymptomatic' named entity 'H1N1' named entity 'pneumoviruses' named entity 'neuraminidase' named entity 'cell culture' named entity 'fever' named entity 'H1N1' named entity 'amino acid' named entity 'Canada' named entity 'June 23' named entity 'infection' named entity 'index case' named entity 'young adult' named entity 'H1N1' named entity 'viral genomes' named entity 'respiratory symptoms' named entity 'index case' named entity 'Sequencher' named entity 'maximum parsimony' named entity 'Barcelonnette' named entity 'H3N2' named entity 'H3N2' named entity 'epidemic curve' named entity 'index case' named entity 'sequenced'

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