About: Respiratory syncytial virus subtype ON1/NA1/BA9 predominates in hospitalized children with lower respiratory tract infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory syncytial virus subtype ON1/NA1/BA9 predominates in hospitalized children with lower respiratory tract infections
Creator	Zhang, Jian Chen, Lijuan Wen, Bo Wang, Chuan Fan, Chuping Fan, Ruyan Liu, Chan Liu, Wenpei Qu, Xiaowang Lei, Yefei
source	Medline; PMC
abstract	Respiratory syncytial virus (RSV) infection is the leading cause of acute respiratory tract disease in children less than 5 years old. The aim of this study was to further elucidate the molecular properties and clinical characteristics of RSV infection. The study sample included 238 patients <5 years old who were hospitalized with clinical symptoms of upper or lower respiratory tract infection (URTI or LRTI) in the Pediatric Department at the First People's Hospital of Chenzhou, South China in 2014. We subjected nasopharyngeal aspirate (NPA) or nasal swab (NS) samples from the patients to indirect fluorescence assay screens. RSV G genes were amplified by reverse transcription‐PCR (RT‐PCR) and sequenced. Of the 238 patients screened, 64 (26.8%) were confirmed to have RSV infections. Of those 64 confirmed RSV infection cases, 39 (60.9%) had subtype BA9, 13 (20.3%) had the recently identified subtype ON1, 11 (17.2%) had subtype NA1, and 1 (1.6%) had subtype GB2. The predominant presentation was LRTI with coughing, sputum production, fever, and wheezing. RSV subtype NA1 and BA9 infections were found mostly in infants, whereas the age distribution of subtype ON1 infections was more uniform across the age bands. Phylogenetic analysis indicated that, compared with the prototype strain A2, all ON1 and most NA1 isolates had lost one potential N‐glycosylation site at amino acid 251 and 249 due to T251K and N249Y substitution, respectively. These findings suggest that NA1, BA9, and ON1 are the dominant RSV subtypes causing respiratory tract infections in young children presenting to the hospital in South China. J. Med. Virol. 89:213–221, 2017. © 2016 Wiley Periodicals, Inc.
has issue date	2016-07-06(xsd:dateTime)
bibo:doi	10.1002/jmv.24619
bibo:pmid	27358012
has license	no-cc
sha1sum (hex)	1d1ec74fa5b33968cea773d37a3a74570a983784
schema:url	https://doi.org/10.1002/jmv.24619
resource representing a document's title	Respiratory syncytial virus subtype ON1/NA1/BA9 predominates in hospitalized children with lower respiratory tract infections
has PubMed Central identifier	PMC7166484
has PubMed identifier	27358012
schema:publication	J Med Virol
resource representing a document's body	covid:1d1ec74fa5b33968cea773d37a3a74570a983784#body_text
is schema:about of	named entity 'screens' named entity 'production' named entity 'South' named entity 'isolates' named entity 'lost' named entity 'BA9' named entity 'sequenced' named entity 'aim' named entity 'acid' named entity 'distribution' named entity 'These' named entity 'causing' named entity 'infections' named entity 'China' named entity 'subtype' named entity 'Infections' named entity 'Respiratory Syncytial Virus' named entity 'nasopharyngeal aspirate' named entity 'BA9' named entity 'young children' named entity 'Phylogenetic analysis' named entity 'RSV infection' named entity 'LRTI' named entity 'BA9' named entity 'URTI' named entity 'LRTI' named entity 'nasal swab' named entity 'infection' named entity 'infection' named entity 'China' named entity 'genotype' named entity 'Venter' named entity 'Shanghai' named entity 'RSV' named entity 'NCBI' named entity 'RSV' named entity 'PCR' named entity 'antisense' named entity 'NXT' named entity 'PCR' named entity 'PCR' named entity 'RSV' named entity 'RSV' named entity 'G-protein' named entity 'genetic characteristics' named entity 'genetic diversity' named entity 'wheezing' named entity 'G-protein' named entity 'URTI' named entity 'Buenos Aries' named entity 'gene duplication' named entity 'genotypes' named entity 'RSV' named entity 'nasopharyngeal aspirate' named entity 'amino acid sequences' named entity 'wheezing' named entity 'RSV' named entity 'single-stranded, negative-sense RNA' named entity 'genetically distinct' named entity 'BA9' named entity 'GA2' named entity 'nucleotides' named entity 'Bacteria' named entity 'RSV' named entity 'amino acids' named entity 'amino acids' named entity 'RSV' named entity 'BA9' named entity 'variable region' named entity 'RSV' named entity 'China' named entity 'wheezing'

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