About: Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity
Creator	Nagarkatti, Mitzi Byrareddy, Siddappa Singh, Narendra Alghetaa, Hasan Mohammed, Amira Sultan, Muthanna Gorantla, Santhi Kaempfer, Raymond
Source	Medline; PMC
abstract	Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydrocannabinol (THC), a psychoactive ingredient found in Cannabis sativa, has been shown to act as a potent anti-inflammatory agent. In the current study, we investigated the effect of THC treatment on SEB-induced ARDS in mice. While exposure to SEB resulted in acute mortality, treatment with THC led to 100% survival of mice. THC treatment significantly suppressed the inflammatory cytokines, IFN-γ and TNF-α. Additionally, THC elevated the induction of regulatory T cells (Tregs) and their associated cytokines, IL-10 and TGF-β. Moreover, THC caused induction of Myeloid-Derived Suppressor Cells (MDSCs). THC acted through CB2 receptor as pharmacological inhibitor of CB2 receptors blocked the anti-inflammatory effects. THC-treated mice showed significant alterations in the expression of miRNA (miRs) in the lung-infiltrated mononuclear cells (MNCs). Specifically, THC caused downregulation of let7a-5p which targeted SOCS1 and downregulation of miR-34-5p which caused increased expression of FoxP3, NOS1, and CSF1R. Together, these data suggested that THC-mediated alterations in miR expression in the lungs may play a critical role in the induction of immunosuppressive Tregs and MDSCs as well as suppression of cytokine storm leading to attenuation of SEB-mediated lung injury.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.3389/fphar.2020.00893
bibo:pmid	32612530
has license	cc-by
sha1sum (hex)	1d747213cb75667c6428a0411c5af6933641859f
schema:url	https://doi.org/10.3389/fphar.2020.00893
resource representing a document's title	Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity
has PubMed Central identifier	PMC7308536
has PubMed identifier	32612530
schema:publication	Front Pharmacol
resource representing a document's body	covid:1d747213cb75667c6428a0411c5af6933641859f#body_text
is schema:about of	named entity 'Cells' named entity 'caused' named entity 'IFN-g' named entity 'lungs' named entity 'regulatory T cells' named entity 'miRNA' named entity 'severe' covid:arg/1d747213cb75667c6428a0411c5af6933641859f named entity 'cytokines' named entity 'expression' named entity 'lung injury' named entity 'investigated' named entity 'superantigen' named entity 'CB2' named entity 'survival' named entity 'complication' named entity 'data' named entity 'TGF-b' named entity 'THC' named entity 'Tetrahydrocannabinol' named entity 'Staphylococcal Enterotoxin B' named entity 'lung' named entity 'lung injury' named entity 'mice' named entity 'pharmacological' named entity 'THC' named entity 'ARDS' named entity 'CB2' named entity 'downregulation' named entity 'bacteria' named entity 'THC' named entity 'mice' named entity 'Acute Respiratory Distress Syndrome' named entity 'THC' named entity 'Tregs' named entity 'Myeloid-Derived Suppressor Cells' named entity 'CSF1R' named entity 'mice' named entity 'anti-inflammatory' named entity 'Tetrahydrocannabinol' named entity 'Cytokines' named entity 'infection' named entity 'SEB' named entity 'FoxP3' named entity 'anti-inflammatory' named entity 'Institutional Animal Care and Use Committee' named entity 'IL-10' named entity 'regulatory T cells' named entity 'Qiagen' named entity 'Treg' named entity 'SR144528' named entity 'Arad' named entity 'qRT-PCR' named entity 'MDSCs' named entity 'miR-34a' named entity 'RNase H' named entity 'FoxP3' named entity 'Venn diagram' named entity 'apoptosis' named entity 'Life Technologies' named entity 'ARDS' named entity 'IACUC' named entity 'Invitrogen' named entity 'SEB' named entity 'reagent' named entity 'upregulation' named entity 'SEB' named entity 'MNCs' named entity 'animal models' named entity 'negative role' named entity 'THC' named entity 'IFN-g' named entity 'PCR' named entity 'lethargy'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software